Abdelkader Omar, Abuzenah Hamza, Shuhaiber Hans
Department of Neurology, Mayo Clinic, Jacksonville, USA.
Internal Medicine, Yarmouk University, Amman, JOR.
Cureus. 2024 Jul 11;16(7):e64310. doi: 10.7759/cureus.64310. eCollection 2024 Jul.
Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) is a rare central nervous system inflammatory condition usually presenting with a range of symptoms, including ataxia, diplopia, dysarthria, seizures, and headaches. We present a unique case of a 22-year-old woman exhibiting headache as the sole symptom. Imaging and biopsy confirmed the diagnosis, and initial steroid treatment provided relief, though it relapsed on tapering. Long-term management with low-dose steroids and mycophenolate mofetil achieved remission. This case highlights the importance of recognizing atypical presentations of CLIPPERS, emphasizing the need for prompt diagnosis and appropriate treatment plans to improve patient outcomes. Further research is necessary to enhance our understanding and management of CLIPPERS.
类固醇反应性桥脑周围血管强化的慢性淋巴细胞性炎症（CLIPPERS）是一种罕见的中枢神经系统炎性疾病，通常表现出一系列症状，包括共济失调、复视、构音障碍、癫痫发作和头痛。我们报告了一例独特的病例，一名22岁女性仅以头痛为唯一症状。影像学检查和活检确诊了该病，初始类固醇治疗缓解了症状，但减量时病情复发。低剂量类固醇和霉酚酸酯的长期治疗实现了病情缓解。该病例突出了认识CLIPPERS非典型表现的重要性，强调了及时诊断和制定适当治疗方案以改善患者预后的必要性。需要进一步研究以加深我们对CLIPPERS的理解和管理。
