McGill University, Department of Mechanical Engineering, 845 Sherbrooke St. W, Montreal, Quebec, Canada, H3A 0G4.
McGill University, Department of Mechanical Engineering, 845 Sherbrooke St. W, Montreal, Quebec, Canada, H3A 0G4.
J Biomech. 2022 May;137:111096. doi: 10.1016/j.jbiomech.2022.111096. Epub 2022 Apr 21.
Intra-abdominal hypertension has been recorded in between 20 and 50% of intensive care unit patients, with rates increasing in ventilated patients. This increased intra-abdominal pressure (IAP) can reduce blood flow to vital organs, perpetuating further pressure build-up as organs become unable to drain excess fluids. Measurement of IAP for the diagnosis of intra-abdominal hypertension remains highly invasive, thus, a non-invasive alternative to traditional IAP measurement was developed and validated, herein. Fourteen living participants and 13 cadaveric specimen were tested with this novel device for IAP measurement. Living participant results were compared to published IAP averages, while cadavers were tested against the existing gold standard: intra-vesical pressure (IVP). Intra- and inter-rater reliability in both living and cadaveric tests presented excellent results. Convergent validity against published IAP values was also excellent (in living participants) and moderate (in cadavers), while convergent validity against IVP was inconclusive. These promising results support the interest in further research, particularly with IVP comparisons in living participants.
腹腔内高压在重症监护病房患者中约有 20%至 50%，在接受通气治疗的患者中比例增加。这种增加的腹腔内压力（IAP）会减少流向重要器官的血流量，使器官无法排出多余的液体，从而进一步加剧压力积聚。目前，腹腔内高压的诊断仍然高度依赖有创测量，因此，人们开发并验证了一种替代传统 IAP 测量的非侵入性方法。本研究使用该新型设备对 14 名活体参与者和 13 具尸体标本进行了 IAP 测量。将活体参与者的结果与已发表的 IAP 平均值进行比较，而将尸体与现有的金标准：膀胱内压（IVP）进行比较。活体和尸体测试的组内和组间可靠性均显示出优异的结果。与已发表的 IAP 值的收敛有效性也非常好（在活体参与者中），中度（在尸体中），而与 IVP 的收敛有效性尚无定论。这些有希望的结果支持进一步研究的兴趣，特别是与活体参与者的 IVP 比较。
