Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Mult Scler Relat Disord. 2022 Jul;63:103824. doi: 10.1016/j.msard.2022.103824. Epub 2022 Apr 25.
Internuclear ophthalmoparesis (INO) occurs in 15-52% of individuals with multiple sclerosis (MS) and is reliably detected by infrared oculography. Methods for diagnosing INO with infrared oculography and the association between INO and MS characteristics need confirmation. We aimed to describe INO prevalence and the clinical characteristics of individuals with MS and INO in a population-based cohort of individuals with MS born in the year 1966 (Project Y).
Previously described thresholds for the versional dysconjugacy index (VDI), assessed with standardized infrared oculography, were used to detect INO in participants of project Y. Clinical characteristics, visual functioning and complaints were compared between individuals with MS with INO and individuals with MS without INO.
Two-hundred-twenty individuals with MS and 110 healthy controls were included. VDI values exceeding the threshold for INO presented in 53 (24%) individuals with MS and 19 controls (13%). INO was associated with male sex, greater disability, worse cognition and worse arm function in individuals with MS. There was no association with disease duration, visual functioning or complaints.
INO is prevalent among individuals with MS aged fifty-three and related to clinical characteristics of MS. INO was more frequently detected in healthy controls than previous studies, implying that oculography based diagnosis of INO requires further refinement.
核间性眼肌麻痹（INO）在 15-52%的多发性硬化症（MS）患者中发生，通过红外眼动描记术可可靠地检测到。需要确认使用红外眼动描记术诊断 INO 的方法以及 INO 与 MS 特征之间的关联。我们旨在描述基于人群的 1966 年出生的 MS 患者队列（项目 Y）中 INO 的患病率以及 INO 患者的 MS 临床特征。
先前描述的用于评估视差失调指数（VDI）的阈值，通过标准化的红外眼动描记术进行评估，用于检测项目 Y 参与者中的 INO。比较 INO 患者与无 INO 患者的 MS 临床特征、视觉功能和症状。
共纳入 220 名 MS 患者和 110 名健康对照者。53 名（24%）MS 患者和 19 名对照者（13%）的 VDI 值超过 INO 的阈值。INO 与 MS 患者中的男性、更高的残疾程度、更差的认知和手臂功能有关。与疾病持续时间、视觉功能或症状无关。
INO 在 53 岁的 MS 患者中较为常见，与 MS 的临床特征相关。INO 在健康对照者中的检出率高于既往研究，这意味着基于眼动描记术的 INO 诊断需要进一步改进。
