Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology, 1830 E. Monument Street, Suite 7500, Baltimore, MD, 21205, USA.
Curr Opin Pharmacol. 2022 Jun;64:102225. doi: 10.1016/j.coph.2022.102225. Epub 2022 Apr 28.
Therapeutic drug monitoring (TDM) is not yet accepted by systemic lupus erythematosus (SLE) treatment guidelines. Studies in SLE, however, have proven benefit in three areas: identification of non-adherence or poor adherence; targets for clinical benefit; and ranges of toxicity. This review covers the data on three medications commonly used for SLE, drawing on studies from both the SLE and non-SLE literature.
治疗药物监测(TDM)尚未被系统性红斑狼疮(SLE)治疗指南所接受。然而,SLE 领域的研究已经证明了在三个方面的益处:识别不依从或依从性差;临床获益的目标;以及毒性范围。这篇综述涵盖了三种常用于 SLE 的药物的数据,借鉴了 SLE 和非 SLE 文献中的研究。