Chen Yang, Zeng Lizhong, Wang Wei, Yuan Jingyan, Sun Ruiying, Yang Shuanying
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Department of Physical Examination, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Pathol Res Pract. 2022 Jun;234:153921. doi: 10.1016/j.prp.2022.153921. Epub 2022 Apr 27.
This study aimed to investigate the role of DEAD-box helicase 47 (DDX47) in lung adenocarcinoma (LUAD). Our results demonstrated that DDX47 was highly expressed in LUAD tissues, and its high expression predicted a poor prognosis. Bioinformatics analysis indicated that DDX47 involved RNA processing and cell division. Furthermore, knockdown of DDX47 reduced cell proliferation and migration in vitro. In sum, our data confirmed the cancer-promoting effect of DDX47.
本研究旨在探讨DEAD盒解旋酶47（DDX47）在肺腺癌（LUAD）中的作用。我们的结果表明，DDX47在LUAD组织中高表达，其高表达预示着预后不良。生物信息学分析表明，DDX47参与RNA加工和细胞分裂。此外，敲低DDX47可降低体外细胞增殖和迁移。总之，我们的数据证实了DDX47的促癌作用。
