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高 GNG4 表达与肺腺癌患者的预后不良相关。

High GNG4 expression is associated with poor prognosis in patients with lung adenocarcinoma.

机构信息

Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.

Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

出版信息

Thorac Cancer. 2022 Feb;13(3):369-379. doi: 10.1111/1759-7714.14265. Epub 2021 Dec 23.

DOI:10.1111/1759-7714.14265
PMID:34951127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8807281/
Abstract

BACKGROUND

The purpose of this study was to explore the reason for guanine nucleotide binding-protein gamma subunit-4 (GNG4) overexpression and the relationship between GNG4 overexpression and the poor prognosis of lung adenocarcinoma (LUAD) patients.

METHODS

The genes and phenotypes related to GNG4 expression in patients with lung adenocarcinoma were analyzed by bioinformatics. The phenotype indicated by bioinformatic analysis was confirmed by experiments.

RESULTS

GNG4 expression is elevated in lung adenocarcinoma, and overexpressed GNG4 is related to the poor prognosis of patients with lung adenocarcinoma. The hypoxic microenvironment of lung adenocarcinoma can promote GNG4 expression and GNG4 promotes the migration and proliferation of lung adenocarcinoma cells.

CONCLUSIONS

GNG4 expression in lung adenocarcinoma was significantly higher than in paired adjacent tissues. GNG4 overexpression is associated with a variety of malignant phenotypes of lung adenocarcinoma. Increased GNG4 expression is related to the hypoxic microenvironment in lung adenocarcinoma.

摘要

背景

本研究旨在探讨鸟嘌呤核苷酸结合蛋白γ亚基 4（GNG4）过表达的原因，以及 GNG4 过表达与肺腺癌（LUAD）患者预后不良之间的关系。

方法

通过生物信息学分析肺腺癌患者中与 GNG4 表达相关的基因和表型，通过实验验证生物信息学分析所提示的表型。

结果

GNG4 在肺腺癌中表达上调，过表达的 GNG4 与肺腺癌患者的预后不良相关。肺腺癌的缺氧微环境可以促进 GNG4 的表达，GNG4 促进肺腺癌细胞的迁移和增殖。

结论

肺腺癌中 GNG4 的表达明显高于配对的癌旁组织。GNG4 过表达与肺腺癌的多种恶性表型相关。GNG4 表达增加与肺腺癌的缺氧微环境有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/9f3f31e62b82/TCA-13-369-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/d021f77e39fe/TCA-13-369-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/34e9e2f4c8a0/TCA-13-369-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/1a43229717f8/TCA-13-369-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/7c707f37080d/TCA-13-369-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/e3f53da27afa/TCA-13-369-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/9f3f31e62b82/TCA-13-369-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/d021f77e39fe/TCA-13-369-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/34e9e2f4c8a0/TCA-13-369-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/1a43229717f8/TCA-13-369-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/7c707f37080d/TCA-13-369-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/e3f53da27afa/TCA-13-369-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e0/8807281/9f3f31e62b82/TCA-13-369-g005.jpg

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