大花玉兰中倍半萜内酯及其独特的原阿朴啡 hybrids 及其抗炎活性。
Sesquiterpene lactone and its unique proaporphine hybrids from Magnolia grandiflora L. and their anti-inflammatory activity.
机构信息
Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
出版信息
Phytochemistry. 2022 Aug;200:113211. doi: 10.1016/j.phytochem.2022.113211. Epub 2022 Apr 29.
Two undescribed sesquiterpene lactone-proaporphine hybrid skeletons, two undescribed sesquiterpenes, and four known compounds were isolated from the aerial part of Magnolia grandiflora L. The structures of isolated compounds were unambiguously determined based on the interpretation of a combination of NMR spectroscopy, HRESIMS, DP4+ probability calculation of carbon data, X-ray crystallographic analyses, and ECD calculation. The isolated compounds were investigated for their anti-inflammatory activity against nitric oxide production and the protein expression of COX-2 in LPS-stimulated RAW 264.7 cells.
从玉兰Magnolia grandiflora L 的地上部分分离得到两个未描述的倍半萜内酯-原阿朴啡混合骨架、两个未描述的倍半萜和四个已知化合物。根据 NMR 光谱、HRESIMS、DP4+碳数据概率计算的组合、X 射线晶体学分析和 ECD 计算的解释，明确确定了分离化合物的结构。对分离得到的化合物进行了抗炎活性研究，测定其对 LPS 刺激的 RAW 264.7 细胞中一氧化氮产生和 COX-2 蛋白表达的抑制作用。
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