Terai C, Nojima Y, Takano K, Yamada A, Takaku F
Clin Nephrol. 1987 Feb;27(2):79-83.
In an attempt to evaluate subclinical lupus nephropathy, we determined the level of urinary albumin by radioimmunoassay in 27 patients with systemic lupus erythematosus (SLE) who had no evidence of clinical renal involvement. The ratio of urinary albumin to urinary creatinine (Ualb/Ucreat X 100) was significantly higher in patients with SLE (2.56 +/- 2.71) than in normal controls (0.83 +/- 0.72). A significant decrease of urinary albumin level in response to steroid therapy was demonstrated in 5 patients examined repeatedly before and during steroid treatment. In one patient who had two episodes of exacerbations of the disease the urinary albumin level increased parallel with a worsening of the serological data and the appearance of clinical proteinuria followed. It is concluded that many SLE patients even without clinical renal involvement have pathologic albuminuria and the determination of the urinary albumin level by radioimmunoassay in these patients is useful for the management of the disease.
为了评估亚临床狼疮性肾炎，我们采用放射免疫分析法测定了27例无临床肾脏受累证据的系统性红斑狼疮（SLE）患者的尿白蛋白水平。SLE患者尿白蛋白与尿肌酐的比值（Ualb/Ucreat×100）（2.56±2.71）显著高于正常对照组（0.83±0.72）。在5例接受类固醇治疗前后反复检查的患者中，显示类固醇治疗后尿白蛋白水平显著下降。有1例患者疾病发作2次，尿白蛋白水平随着血清学数据恶化而升高，随后出现临床蛋白尿。结论是，许多SLE患者即使无临床肾脏受累也存在病理性蛋白尿，对这些患者采用放射免疫分析法测定尿白蛋白水平有助于疾病的管理。
