Stoica G H, Purice S, Cheţa D, Serban M, Balea M, Michiu V
Med Interne. 1984 Jan-Mar;22(1):19-28.
Urinary excretion of albumin was determined in 133 clinically healthy subjects and 236 patients suffering from diabetes mellitus (150 cases), collagen diseases (45 cases), or arterial hypertension (41 cases) in whom there was no clinical or laboratory evidence of renal involvement. Urine albumin was measured by an improved single-radial-immunodiffusion technique and results were expressed as urine albumin to creatinine concentration ratio (mg/g). The geometric mean values in the patients were about 2 to 2.5 times higher than in controls. When considered on an individual basis, at least 40 per cent of the patients had values above the 99th-percentile value for controls. The results suggest that quantitative determination of urinary albumin may be useful for detecting early structural functional alterations of the glomerular filter.
对133名临床健康受试者以及236名患有糖尿病（150例）、胶原病（45例）或动脉高血压（41例）且无肾脏受累临床或实验室证据的患者测定了尿白蛋白排泄量。采用改良的单向放射免疫扩散技术测定尿白蛋白，并将结果表示为尿白蛋白与肌酐浓度比（mg/g）。患者的几何平均值比对照组高约2至2.5倍。就个体而言，至少40%的患者的值高于对照组第99百分位数的值。结果表明，尿白蛋白的定量测定可能有助于检测肾小球滤过器的早期结构功能改变。
