Department of Mechanical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
Bone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Injury. 2022 Jun;53(6):1815-1823. doi: 10.1016/j.injury.2022.04.019. Epub 2022 Apr 22.
In the early stage of fracture fixation, the aim of a unilateral external fixator (UEF) to stimulate healing and maintain stability may be suppressed by using inadequate number of pins. Cortical thinning due to age or osteoporosis endangers a successful fracture fixation.
This study evaluates the initial strength and stability of the fracture fixation and tissue differentiation under the influences of variable cortical thickness (5 mm to 1 mm) and variable number of pins (1 to 4 in each bone fragment). A finite element program was utilised to develop 20 three-dimensional models of simplified diaphyseal tibia with fracture callus fixed with UEF. A mechano-regulation code based on the deviatoric strain theory was written and applied to simulate tissue differentiation. The values of von Mises stress, interfragmentary strain (IFS), and fibrocartilage index (FCI) were evaluated.
Cortical thinning from 5 mm to 1 mm increased IFS and FCI by an average of 30.3% and 18.7%, respectively, and resulted in higher stresses in the UEF and bone. Using 1 pin in each bone fragment produced excessive IFS in the models with 1 mm, 2 mm and 3 mm cortical thickness. Inserting the second pin into the bone fragment could considerably reduce the IFS and fibrocartilaginous tissue formation in the fracture site and improve load transmission to the fixator. Whereas inserting the fourth pin could minimally affect the mechano-biological environment of healing.
This study suggests that initial instability due to cortical thinning can be efficiently alleviated by adding the number of pins up to 3 in a UEF; additionally, it may improve the knowledge about applying UEFs adequately stable, whilst promoting inclination toward endochondral ossification, simultaneously.
在骨折固定的早期,单侧外固定器(UEF)刺激愈合和维持稳定性的目的可能会因使用的固定针数量不足而受到抑制。由于年龄或骨质疏松导致的皮质变薄会危及骨折固定的成功。
本研究评估了可变皮质厚度(5 毫米至 1 毫米)和可变固定针数量(每个骨段 1 至 4 根)对骨折固定初始强度和稳定性以及组织分化的影响。利用有限元程序开发了 20 个简化的骨干胫骨三维模型,骨折痂用 UEF 固定。编写了一个基于偏应变理论的机械调节代码,并应用于模拟组织分化。评估了 von Mises 应力、骨段间应变(IFS)和纤维软骨指数(FCI)的值。
皮质从 5 毫米减薄至 1 毫米使 IFS 和 FCI 平均分别增加 30.3%和 18.7%,导致 UEF 和骨骼中的应力更高。在皮质厚度为 1 毫米、2 毫米和 3 毫米的模型中,每个骨段使用 1 根固定针会产生过大的 IFS。在骨段中插入第二根固定针可以显著减少骨折部位的 IFS 和纤维软骨组织形成,并改善向固定器的负荷传递。而插入第四根固定针对愈合的力学生物学环境的影响最小。
本研究表明,由于皮质变薄导致的初始不稳定性可以通过在 UEF 中增加到 3 根固定针的数量来有效缓解;此外,它可能会增加关于使用 UEF 充分稳定的知识,同时促进向软骨内骨化的倾向。