Wilkus R J, Dodrill C B, Troupin A S
Epilepsia. 1978 Jun;19(3):283-91. doi: 10.1111/j.1528-1157.1978.tb04491.x.
In double blind crossover 4 month trials, carbamazepine was compared to phenytoin as sole treatment for 45 patients with uncontrolled partial and generalized epilepsy. EEGs performed at the end of these trials revealed that while using carbamazepine the patients manifested a significant overall increase in diffuse slow waves and an increase in generalized epileptiform discharges without significant accompanying changes in seizure incidence. Also, during the carbamazepine trial generalized epileptiform discharges activated by hyperventilation were more frequent in patients with a higher seizure incidence compared to subjects with a lower seizure incidence of patients taking phenytoin. No significant focal EEG changes occurred.
在为期4个月的双盲交叉试验中，对45例部分性和全身性癫痫控制不佳的患者，将卡马西平与苯妥英钠作为单一治疗药物进行了比较。这些试验结束时进行的脑电图检查显示，使用卡马西平期间，患者弥漫性慢波总体显著增加，全身性癫痫样放电增加，而癫痫发作发生率无显著伴随变化。此外，在卡马西平试验期间，与服用苯妥英钠且癫痫发作发生率较低的患者相比，癫痫发作发生率较高的患者因过度换气激活的全身性癫痫样放电更为频繁。未出现明显的局灶性脑电图变化。
