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Excellent response to β-1 adrenergic receptor blockade (metoprolol) and exercise restriction in high-risk type 1 long QT syndrome. A 22-year follow-up.

作者信息

Tejeda-Mollinedo Williams, Díaz-Tostado Sergio, Gómez-Flores Jorge, Nava-Townsend Santiago, Levinstein-Jacinto Moises, Márquez Manlio F

机构信息

Department of Electrophysiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

出版信息

HeartRhythm Case Rep. 2021 Dec 11;8(3):191-194. doi: 10.1016/j.hrcr.2021.12.006. eCollection 2022 Mar.

DOI:10.1016/j.hrcr.2021.12.006
PMID:35492848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9039562/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/462b/9039562/dd2b9f07aa34/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/462b/9039562/41582a07bb72/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/462b/9039562/5ba35c3bd57a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/462b/9039562/dd2b9f07aa34/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/462b/9039562/41582a07bb72/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/462b/9039562/5ba35c3bd57a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/462b/9039562/dd2b9f07aa34/gr3.jpg

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[Congenital long QT syndrome].[先天性长QT综合征]
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Effect of beta-blockers on the relation between QT-interval and heart rate in exercise ECG.β受体阻滞剂对运动心电图中QT间期与心率关系的影响。
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Europace. 2014 Dec;16(12):1847-51. doi: 10.1093/europace/euu086. Epub 2014 May 15.

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本文引用的文献

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Targeted next generation sequencing revealed a novel deletion-frameshift mutation of KCNH2 gene in a Chinese Han family with long QT syndrome: A case report and review of Chinese cases.靶向二代测序揭示了一个中国汉族长QT综合征家系中KCNH2基因的新型缺失移码突变:一例报告并对中国病例进行综述
Medicine (Baltimore). 2020 Apr;99(16):e19749. doi: 10.1097/MD.0000000000019749.
2
Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-analysis.β受体阻滞剂对先天性长QT综合征不同基因型的有效性:一项荟萃分析。
PLoS One. 2017 Oct 23;12(10):e0185680. doi: 10.1371/journal.pone.0185680. eCollection 2017.
3
2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC).
2015年欧洲心脏病学会(ESC)室性心律失常患者管理和心脏性猝死预防指南:欧洲心脏病学会(ESC)室性心律失常患者管理和心脏性猝死预防特别工作组。认可机构:欧洲儿科和先天性心脏病协会(AEPC)。
Eur Heart J. 2015 Nov 1;36(41):2793-2867. doi: 10.1093/eurheartj/ehv316. Epub 2015 Aug 29.
4
Congenital long QT syndromes: prevalence, pathophysiology and management.先天性长 QT 综合征:患病率、病理生理学和治疗。
Paediatr Drugs. 2014 Dec;16(6):447-56. doi: 10.1007/s40272-014-0090-4.
5
Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol.并非所有β受体阻滞剂在 1 型和 2 型长 QT 综合征的管理中都具有同等作用:美托洛尔的事件复发率更高。
J Am Coll Cardiol. 2012 Nov 13;60(20):2092-9. doi: 10.1016/j.jacc.2012.07.046. Epub 2012 Oct 17.
6
High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment "failures".β受体阻滞剂在1型长QT综合征中的高效性:不依从性和延长QT间期药物对β受体阻滞剂治疗“失败”发生的影响。
Circulation. 2009 Jan 20;119(2):215-21. doi: 10.1161/CIRCULATIONAHA.108.772533. Epub 2008 Dec 31.
7
Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome.先天性长QT综合征患儿心脏骤停未遂及心源性猝死的危险因素。
Circulation. 2008 Apr 29;117(17):2184-91. doi: 10.1161/CIRCULATIONAHA.107.701243. Epub 2008 Apr 21.
8
Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene.根据涉及KCNQ1基因的突变的位置、编码类型和生物物理功能,探讨1型长QT综合征的临床特征。
Circulation. 2007 May 15;115(19):2481-9. doi: 10.1161/CIRCULATIONAHA.106.665406. Epub 2007 Apr 30.
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JAMA. 2004 Sep 15;292(11):1341-4. doi: 10.1001/jama.292.11.1341.
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Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome.左心交感神经去神经支配在长QT综合征高危患者管理中的应用
Circulation. 2004 Apr 20;109(15):1826-33. doi: 10.1161/01.CIR.0000125523.14403.1E. Epub 2004 Mar 29.