Department of Chemistry, Synthetic Organic Chemistry Laboratory, MLSU, Udaipur, Rajasthan, India.
Top Curr Chem (Cham). 2024 Feb 25;382(1):8. doi: 10.1007/s41061-024-00454-z.
From a synthetic perspective, bis(indolyl)methanes have undergone extensive investigation over the past two to three decades owing to their remarkable pharmacological activities, encompassing anticancer, antimicrobial, antioxidant, and antiinflammatory properties. These highly desirable attributes have spurred significant interest within the scientific community, leading to the development of various synthetic strategies that are not only more efficient but also ecofriendly. This synthesis-based literature review delves into the advancements made in the past 5 years, focusing on the synthesis of symmetrical as well as unsymmetrical bis(indolyl)methanes. The review encompasses a wide array of methods, ranging from well-established techniques to more unconventional and innovative approaches. Furthermore, it highlights the exploration of various substrates, encompassing readily available chemicals such as indole, aldehydes/ketones, indolyl methanols, etc. as well as the use of some specific compounds as starting materials to achieve the synthesis of this invaluable molecule. By encapsulating the latest developments in this field, this review provides insights into the expanding horizons of bis(indolyl)methane synthesis.
从合成的角度来看，双（吲哚基）甲烷在过去的二三十年中受到了广泛的研究，因为它们具有显著的药理活性，包括抗癌、抗菌、抗氧化和抗炎特性。这些非常理想的特性激发了科学界的极大兴趣，导致了各种合成策略的发展，这些策略不仅更有效，而且更环保。本基于合成的文献综述深入探讨了过去 5 年来的进展，重点介绍了对称和不对称双（吲哚基）甲烷的合成。综述涵盖了广泛的方法，包括从成熟的技术到更非常规和创新的方法。此外，它还强调了对各种底物的探索，包括吲哚、醛/酮、吲哚甲醇等易得的化学物质，以及使用一些特定的化合物作为起始材料来实现这种宝贵分子的合成。通过总结该领域的最新进展，本综述为双（吲哚基）甲烷合成的广阔前景提供了深入的见解。
