Xu Ying, Pei Weiwei, Hu Wentao
State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.
School of Radiation Medicine and Protection, Suzhou University Medical College of Soochow University, Suzhou, China.
Front Cell Dev Biol. 2022 Apr 12;10:861006. doi: 10.3389/fcell.2022.861006. eCollection 2022.
Distinct from Earth's environment, space environmental factors mainly include space radiation, microgravity, hypomagnetic field, and disrupted light/dark cycles that cause physiological changes in astronauts. Numerous studies have demonstrated that space environmental factors can lead to muscle atrophy, bone loss, carcinogenesis, immune disorders, vascular function and cognitive impairment. Most current ground-based studies focused on single environmental factor biological effects. To promote manned space exploration, a better understanding of the biological effects of the spaceflight environment is necessary. This paper summarizes the latest research progress of the combined biological effects of double or multiple space environmental factors on mammalian cells, and discusses their possible molecular mechanisms, with the hope of providing a scientific theoretical basis to develop appropriate countermeasures for astronauts.
与地球环境不同，空间环境因素主要包括空间辐射、微重力、弱磁场以及打乱的光/暗周期，这些因素会导致宇航员出现生理变化。大量研究表明，空间环境因素可导致肌肉萎缩、骨质流失、致癌、免疫紊乱、血管功能和认知障碍。目前大多数地面研究聚焦于单一环境因素的生物学效应。为推动载人航天探索，有必要更好地了解航天环境的生物学效应。本文总结了双因素或多因素空间环境对哺乳动物细胞联合生物学效应的最新研究进展，并探讨其可能的分子机制，以期为制定针对宇航员的适当对策提供科学理论依据。
