Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Jinan, Shandong Province, China.
School of Acupuncture-Tuina, Shandong University of Traditional Chinese, Jinan, Shandong Province, China.
Dis Markers. 2022 Apr 21;2022:1033197. doi: 10.1155/2022/1033197. eCollection 2022.
Although cognitive impairment has received more attention in recent years as a result of spinal cord injury (SCI), the pathogenic process that causes it is still unknown. The neuroprotective effects of Netrin as a family of laminin-related secreted proteins were discovered. The purpose of this study was to determine the changes of serum Netrin-1 after SCI and its relationship with cognitive impairment.
96 SCI patients and 60 controls were included in our study. We collected baseline data from all participants, measured their serum Netrin-1 levels, and followed up their cognitive levels 3 months later.
The clinical baseline values between the control and SCI groups were not significantly different ( > 0.05). However, the serum Netrin-1 level in the SCI group was significantly lower than that in the control group (528.4 ± 88.3 pg/ml vs. 673.5 ± 97.2 pg/ml, < 0.05). According to the quartile level of serum Netrin-1 level in the SCI group, we found that with the increase of serum Netrin-1 level, the MoCA score also increased significantly ( < 0.001), indicating that the serum Netrin-1 level was positively correlated with the MoCA score after SCI. After controlling for baseline data, multiple regression analysis revealed that Netrin-1 remained an independent risk factor for cognitive impairment after SCI (=0.274, = 0.036).
Netrin-1 may be a neuroprotective factor for cognitive impairment, which may serve as a serum marker to predict cognitive impairment after SCI.
由于脊髓损伤（SCI），认知障碍近年来受到了更多的关注，但导致其发生的发病机制仍不清楚。作为层粘连蛋白相关分泌蛋白家族的神经保护蛋白 Netrin 的作用被发现。本研究旨在确定 SCI 后血清 Netrin-1 的变化及其与认知障碍的关系。
纳入 96 例 SCI 患者和 60 例对照。我们从所有参与者收集基线数据，测量他们的血清 Netrin-1 水平，并在 3 个月后随访他们的认知水平。
对照组和 SCI 组的临床基线值无显著差异（>0.05）。然而，SCI 组的血清 Netrin-1 水平明显低于对照组（528.4±88.3 pg/ml 比 673.5±97.2 pg/ml，<0.05）。根据 SCI 组血清 Netrin-1 水平的四分位水平，我们发现随着血清 Netrin-1 水平的升高，MoCA 评分也显著升高（<0.001），表明 SCI 后血清 Netrin-1 水平与 MoCA 评分呈正相关。在控制基线数据后，多元回归分析显示 Netrin-1 仍然是 SCI 后认知障碍的独立危险因素（=0.274，=0.036）。
Netrin-1 可能是认知障碍的神经保护因子，可作为预测 SCI 后认知障碍的血清标志物。
