School of Acupuncture-Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250062, China.
Bone Biomechanics Engineering Laboratory of Shandong Province, Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Jinan 250062, China.
Biomed Res Int. 2021 Feb 5;2021:6653439. doi: 10.1155/2021/6653439. eCollection 2021.
Interleukin-37 (IL-37) inhibits the pathogenesis of rheumatoid arthritis (RA) via downregulating proinflammatory cytokines. Accordingly, we performed an analysis to accurately assess the relationship between serum IL-37 cytokine levels and disease activity of RA. Subgroup analysis and sensitivity analysis were applied to explore the sources of heterogeneity. Correlation coefficient () was utilized to evaluate the relationship between IL-37 and disease activity of RA patients. Ten studies were included into the research. Functional analysis revealed elevated serum IL-37 concentrations in RA patients (SMD = 1.61, < 0.00001). The relationship between serum IL-37 levels and disease activity was statistically significant (C-reactive protein: = 1.47, = 0.0002; erythrocyte sedimentation rate: = 1.55, < 0.00001; rheumatoid factor: = 1.40, = 0.004; tumor necrosis factor⁃: = 1.64, = 0.0003; Disease Activity Score for 28 joints: = 1.63, < 0.00001; tender joint count: = 1.48, < 0.00001; and swollen joint count: = 1.52, = 0.0003), but anti-CCP was not significant (anti-CCP: = 0.98, = 0.72). In summary, these data are suggesting that the elevated serum level of IL-37 in RA is positively correlated with the disease activity of RA, suggesting a role for IL-37in the pathogenesis of RA.
白细胞介素-37（IL-37）通过下调促炎细胞因子抑制类风湿关节炎（RA）的发病机制。因此，我们进行了一项分析，以准确评估血清 IL-37 细胞因子水平与 RA 疾病活动度之间的关系。亚组分析和敏感性分析用于探索异质性的来源。相关系数（）用于评估 IL-37 与 RA 患者疾病活动度之间的关系。有 10 项研究纳入研究。功能分析显示 RA 患者血清 IL-37 浓度升高（SMD = 1.61，<0.00001）。血清 IL-37 水平与疾病活动度之间存在统计学显著相关性（C 反应蛋白：= 1.47，= 0.0002；红细胞沉降率：= 1.55，<0.00001；类风湿因子：= 1.40，= 0.004；肿瘤坏死因子-α：= 1.64，<0.0003；28 关节疾病活动评分：= 1.63，<0.00001；压痛关节计数：= 1.48，<0.00001；肿胀关节计数：= 1.52，= 0.0003），但抗 CCP 不显著（抗 CCP：= 0.98，= 0.72）。总之，这些数据表明，RA 患者血清中 IL-37 水平升高与 RA 的疾病活动度呈正相关，表明 IL-37 在 RA 的发病机制中起作用。
