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Commentary: Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4+ T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation.

作者信息

Stokes Jessica, Simpson Richard J, Katsanis Emmanuel

机构信息

Department of Pediatrics, University of Arizona, Tucson, AZ, United States.

Department of Immunobiology, University of Arizona, Tucson, AZ, United States.

出版信息

Front Immunol. 2022 Apr 14;13:887648. doi: 10.3389/fimmu.2022.887648. eCollection 2022.

DOI:10.3389/fimmu.2022.887648
PMID:35493453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9046566/
Abstract
摘要

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Commentary: Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4+ T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation.述评：移植后环磷酰胺独特地抑制小鼠MHC单倍体相合造血细胞移植后同种异体反应性CD4 + T细胞的增殖和分化。
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2
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Partially replacing cyclophosphamide with bendamustine in combination with cyclosporine A improves survival and reduces xenogeneic graft-versus-host-disease.用苯达莫司汀部分替代环磷酰胺联合环孢素 A 可提高存活率并减少异种移植物抗宿主病。
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本文引用的文献

1
Progressive substitution of posttransplant cyclophosphamide with bendamustine: A phase I study in haploidentical bone marrow transplantation.苯达莫司汀逐步替代移植后环磷酰胺：单倍体相合骨髓移植的I期研究
EJHaem. 2020 May 26;1(1):286-292. doi: 10.1002/jha2.20. eCollection 2020 Jul.
2
Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4 T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation.移植后环磷酰胺独特地抑制小鼠 MHC 单倍体造血细胞移植后同种反应性 CD4 T 细胞的增殖和分化。
Front Immunol. 2022 Feb 15;13:796349. doi: 10.3389/fimmu.2022.796349. eCollection 2022.
3
Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death.苯达莫司汀诱导的调节性树突状细胞与增强的 Flt3 表达和同种异体反应性 T 细胞死亡相关。
Front Immunol. 2021 Jun 24;12:699128. doi: 10.3389/fimmu.2021.699128. eCollection 2021.
4
Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease.整合临床前和临床研究的见解可增进移植物抗宿主病的理解。
J Clin Invest. 2021 Jun 15;131(12). doi: 10.1172/JCI149296.
5
Immunomodulatory Effects of Bendamustine in Hematopoietic Cell Transplantation.苯达莫司汀在造血细胞移植中的免疫调节作用。
Cancers (Basel). 2021 Apr 3;13(7):1702. doi: 10.3390/cancers13071702.
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Graft-versus-Host Disease Prophylaxis with Post-Transplantation Bendamustine in Patients with Refractory Acute Leukemia: A Dose-Ranging Study.移植后苯达莫司汀预防难治性急性白血病患者的移植物抗宿主病：一项剂量范围研究。
Transplant Cell Ther. 2021 Jul;27(7):601.e1-601.e7. doi: 10.1016/j.jtct.2021.03.032. Epub 2021 May 7.
7
Bendamustine Conditioning Skews Murine Host DCs Toward Pre-cDC1s and Reduces GvHD Independently of Batf3.苯达莫司汀预处理使小鼠宿主树突状细胞向 pre-cDC1 分化，并独立于 Batf3 减少移植物抗宿主病。
Front Immunol. 2020 Jul 16;11:1410. doi: 10.3389/fimmu.2020.01410. eCollection 2020.
8
Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia.苯达莫司汀联合全身照射预处理可产生耐受性T细胞，同时保留T细胞依赖性移植物抗白血病效应。
Oncoimmunology. 2020 Apr 30;9(1):1758011. doi: 10.1080/2162402X.2020.1758011. eCollection 2020.
9
Optimized Timing of Post-Transplantation Cyclophosphamide in MHC-Haploidentical Murine Hematopoietic Cell Transplantation.MHC单倍型相同小鼠造血细胞移植中移植后环磷酰胺的优化时机
Biol Blood Marrow Transplant. 2020 Feb;26(2):230-241. doi: 10.1016/j.bbmt.2019.09.030. Epub 2019 Oct 2.
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Impact of Levofloxacin for the Prophylaxis of Bloodstream Infection on the Gut Microbiome in Patients With Hematologic Malignancy.左氧氟沙星预防血流感染对血液系统恶性肿瘤患者肠道微生物群的影响
Open Forum Infect Dis. 2019 May 31;6(7):ofz252. doi: 10.1093/ofid/ofz252. eCollection 2019 Jul.