Department of Pulmonology, University Hospital of Nancy, 54511 Nancy, France.
Development, Adaptation and Disadvantage, Cardiorespiratory Regulations and Motor Control (EA 3450 DevAH), University of Lorraine, 54505 Nancy, France.
Int J Environ Res Public Health. 2021 Jan 23;18(3):992. doi: 10.3390/ijerph18030992.
: Tobacco smoking is associated with more severe asthma symptoms, an accelerated decline in lung function, and reduced responses to corticosteroids. Our objective was to compare asthma outcomes in terms of disease control, exacerbation rates, and lung function in a population of asthmatic patients according to their smoking status. : We compared patients' demographics, disease characteristics, and lung-function parameters in current-smokers (CS, = 48), former-smokers (FS, = 38), and never-smokers (NS, = 90), and identified predictive factors for asthma control. : CS had a higher prevalence of family asthma/atopy, a lower rate of controlled asthma, impaired perception of dyspnea, an increased number of exacerbations, and poorer lung function compared to NS. The mean asthma control questionnaire's (ACQ) score was higher in CS vs. NS and FS (1.9 vs. 1.2, = 0.02). Compared to CS, FS had a lower rate of exacerbations, a better ACQ score (similar to NS), a higher prevalence of dyspnea, and greater lung-diffusion capacity. Non-smoking status, the absence of dyspnea and exacerbations, and a forced expiratory volume in one second ≥80% of predicted were associated with controlled asthma. : CS with asthma exhibit worse clinical and functional respiratory outcomes compared to NS and FS, supporting the importance of smoking cessation in this population.
吸烟与更严重的哮喘症状、肺功能加速下降和皮质类固醇反应降低有关。我们的目的是根据吸烟状况比较哮喘患者的疾病控制、加重率和肺功能等哮喘结局。
我们比较了当前吸烟者（CS，n=48）、曾经吸烟者（FS，n=38）和从不吸烟者（NS，n=90）的患者人口统计学、疾病特征和肺功能参数，并确定了哮喘控制的预测因素。
CS 组家族哮喘/过敏史的患病率较高，哮喘控制率较低，呼吸困难感知能力受损，加重次数增加，肺功能较差。CS 组的平均哮喘控制问卷（ACQ）评分高于 NS 和 FS 组（1.9 比 1.2，p=0.02）。与 CS 组相比，FS 组的加重率较低，ACQ 评分较高（与 NS 组相似），呼吸困难的患病率较高，肺扩散能力较大。不吸烟状态、无呼吸困难和加重、一秒用力呼气量≥预计值的 80%与哮喘控制有关。
与 NS 和 FS 相比，患有哮喘的 CS 患者表现出更差的临床和功能呼吸结局，这支持在该人群中戒烟的重要性。
