人类神经胶质细胞对人类免疫缺陷病毒（HIV）感染的易感性。

Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV).

作者信息

Dewhurst S, Bresser J, Stevenson M, Sakai K, Evinger-Hodges M J, Volsky D J

出版信息

FEBS Lett. 1987 Mar 9;213(1):138-43. doi: 10.1016/0014-5793(87)81479-5.

Abstract

Three human brain-derived cell lines (including two of astrocytic origin) were exposed in vitro to the human immunodeficiency virus (HIV), the etiologic agent of immunodeficiency in AIDS. In all three lines, HIV transcripts were detected by in situ hybridisation in 20-30% of cells 48 h after infection. Synthesis of virus gag gene products p24 and p55 was demonstrated by immunoblotting. No cytopathic effects typical of HIV-infected human T lymphocytes were observed. Our data indicate that HIV is neurotropic, and support the hypothesis that this virus may infect astrocytes in the brain.

摘要

三种源自人脑的细胞系（包括两种星形胶质细胞起源的细胞系）在体外暴露于人类免疫缺陷病毒（HIV），即艾滋病免疫缺陷的病原体。在所有这三种细胞系中，感染后48小时，通过原位杂交在20%至30%的细胞中检测到HIV转录本。通过免疫印迹证实了病毒gag基因产物p24和p55的合成。未观察到HIV感染的人类T淋巴细胞典型的细胞病变效应。我们的数据表明HIV具有嗜神经性，并支持该病毒可能感染脑内星形胶质细胞的假说。