Farazin Ashkan, Mohammadimehr Mehdi, Ghasemi Amir Hossein, Naeimi Hossein
Department of Solid Mechanics, Faculty of Mechanical Engineering, University of Kashan P.O. Box 87317-53153 Kashan Iran
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan P.O. Box 87317-53153 Kashan Iran.
RSC Adv. 2021 Oct 6;11(52):32775-32791. doi: 10.1039/d1ra05153a. eCollection 2021 Oct 4.
One of the most significant factors affecting the rapid and effective healing of wounds is the application of appropriate wound dressings. In the present study, novel antibacterial wound dressings are fabricated that consist of Chitosan (CS)/Polyvinyl alcohol (PVA)/Sodium Alginate (SA), which are all biocompatible, functionalized with mesoporous AgO/SiO and curcumin nanoparticles as reinforcements. In this research nanocomposites are fabricated (0 wt%, 5 wt%, 10 wt%, 15 wt%, and 20 wt% of AgO/SiO). After the composition of nanocomposites using the cross-linked technique, Fourier Transform Infrared (FT-IR) spectroscopy is performed to confirm the functional groups that are added to the polymer at each step. X-ray diffraction (XRD) is done to show the crystallinity of AgO/SiO. Field emission scanning electron microscopy (FE-SEM) studies are performed to demonstrate the morphology of the structure, Energy-dispersive X-ray spectroscopy (EDS) is done to examine the elements in the wound dressing and atomic force microscopy (AFM) study is performed to show surface roughness and pores. Then the nanocomposites with different weight percentages are cultured in three bacteria called , , and , all three of which cause skin infections. Finally, by performing the tensile test, the results related to the tensile strength of the wound dressings are examined. The results show that with the increase of AgO/SiO, the mechanical properties, as well as the healing properties of the wound dressing, have increased significantly. Fabricating these nanocomposites helps a lot in treating skin infections.
影响伤口快速有效愈合的最重要因素之一是使用合适的伤口敷料。在本研究中，制备了新型抗菌伤口敷料，其由壳聚糖（CS）/聚乙烯醇（PVA）/海藻酸钠（SA）组成，这些成分均具有生物相容性，并以介孔AgO/SiO和姜黄素纳米颗粒作为增强剂进行功能化处理。在本研究中制备了纳米复合材料（AgO/SiO的含量分别为0 wt%、5 wt%、10 wt%、15 wt%和20 wt%）。在使用交联技术制备纳米复合材料后，进行傅里叶变换红外（FT-IR）光谱分析，以确认在每个步骤中添加到聚合物中的官能团。进行X射线衍射（XRD）分析以显示AgO/SiO的结晶度。进行场发射扫描电子显微镜（FE-SEM）研究以展示结构的形态，进行能量色散X射线光谱（EDS）分析以检测伤口敷料中的元素，并进行原子力显微镜（AFM）研究以显示表面粗糙度和孔隙。然后将不同重量百分比的纳米复合材料在三种名为 、 和 的细菌中培养，这三种细菌都会引起皮肤感染。最后，通过进行拉伸试验，检查与伤口敷料拉伸强度相关的结果。结果表明，随着AgO/SiO含量的增加，伤口敷料的机械性能以及愈合性能均显著提高。制备这些纳米复合材料对治疗皮肤感染有很大帮助。
