单克隆抗体作为胰岛素受体结构与功能的探针 - Suppr

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Monoclonal antibodies as probes of the structure and function of insulin receptors.

作者信息

Siddle K, Soos M A, O'Brien R M, Ganderton R H, Taylor R

出版信息

Biochem Soc Trans. 1987 Feb;15(1):47-51. doi: 10.1042/bst0150047.

DOI:10.1042/bst0150047

PMID:3549387

Abstract

摘要

相似文献

Monoclonal antibodies as probes of the structure and function of insulin receptors.单克隆抗体作为胰岛素受体结构与功能的探针

Biochem Soc Trans. 1987 Feb;15(1):47-51. doi: 10.1042/bst0150047.

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.针对人胰岛素受体的单克隆抗体，其可激活葡萄糖转运但不具备胰岛素受体激酶活性。

Proc Natl Acad Sci U S A. 1987 May;84(10):3448-51. doi: 10.1073/pnas.84.10.3448.

Insulin receptor function is preserved in a physiological state of hypoinsulinemia and insulin resistance.

Am J Physiol. 1992 Jun;262(6 Pt 1):E818-25. doi: 10.1152/ajpendo.1992.262.6.E818.

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.胰岛素的作用被一种抑制胰岛素受体激酶的单克隆抗体所阻断。

Proc Natl Acad Sci U S A. 1986 Jan;83(2):328-32. doi: 10.1073/pnas.83.2.328.

Antibodies to the insulin receptor as tools in the study of receptor structure and function.抗胰岛素受体抗体作为研究受体结构与功能的工具。

Ann N Y Acad Sci. 1987;505:301-12. doi: 10.1111/j.1749-6632.1987.tb51298.x.

Species specificity of insulin binding and insulin receptor protein tyrosine kinase activity.胰岛素结合的物种特异性与胰岛素受体蛋白酪氨酸激酶活性

Endocrinology. 1987 Dec;121(6):2007-10. doi: 10.1210/endo-121-6-2007.

Interactions of a monoclonal antibody to the insulin receptor with receptors for insulin-like growth factors.一种针对胰岛素受体的单克隆抗体与胰岛素样生长因子受体的相互作用。

Endocrinology. 1983 May;112(5):1865-7. doi: 10.1210/endo-112-5-1865.

The subunit structure of the insulin receptor and molecular interactions with major histocompatibility complex antigens.胰岛素受体的亚基结构以及与主要组织相容性复合体抗原的分子相互作用。

Biochimie. 1985 Oct-Nov;67(10-11):1155-9. doi: 10.1016/s0300-9084(85)80114-0.

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.蛋白激酶C在体外直接使胰岛素受体磷酸化，并降低其蛋白酪氨酸激酶活性。

Proc Natl Acad Sci U S A. 1986 Aug;83(16):5822-4. doi: 10.1073/pnas.83.16.5822.

Comparison of solubilized and purified plasma membrane and nuclear insulin receptors.溶解并纯化的质膜和核胰岛素受体的比较。

Biochemistry. 1988 Jan 12;27(1):375-9. doi: 10.1021/bi00401a056.

引用本文的文献

Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy.抗胰岛素受体抗体可改善人类胰岛素受体病小鼠模型的高血糖症。

Diabetes. 2020 Nov;69(11):2481-2489. doi: 10.2337/db20-0345. Epub 2020 Aug 17.

Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models.评估抗胰岛素受体抗体作为潜在的新型治疗方法用于人类胰岛素受体病的细胞培养模型。

Diabetologia. 2018 Jul;61(7):1662-1675. doi: 10.1007/s00125-018-4606-2. Epub 2018 Apr 27.

Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.一种变构单克隆抗体通过增加胰岛素受体结合亲和力在体外和体内改善葡萄糖代谢。

PLoS One. 2014 Feb 12;9(2):e88684. doi: 10.1371/journal.pone.0088684. eCollection 2014.

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.一种人源变构单克隆抗体对胰岛素受体功能的抑制：治疗高胰岛素血症性低血糖的一种新方法。

MAbs. 2014 Jan-Feb;6(1):262-72. doi: 10.4161/mabs.26871.

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.一种全人源、变构的单克隆抗体，可激活胰岛素受体并改善血糖控制。

Diabetes. 2012 May;61(5):1263-71. doi: 10.2337/db11-1578. Epub 2012 Mar 8.

Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.缺乏细胞质β亚基结构域的胰岛素受体介导的跨膜信号传导。

Proc Natl Acad Sci U S A. 1993 May 15;90(10):4379-83. doi: 10.1073/pnas.90.10.4379.

Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor.负性和正性的位点间相互作用，以及它们受pH、胰岛素类似物和单克隆抗体的调节作用，在纯化的胰岛素受体中得以保留。

Proc Natl Acad Sci U S A. 1988 Nov;85(22):8400-4. doi: 10.1073/pnas.85.22.8400.

Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene.在由src癌基因转化的细胞中，胰岛素样生长因子I受体的组成型磷酸化。

Mol Cell Biol. 1990 Jul;10(7):3626-34. doi: 10.1128/mcb.10.7.3626-3634.1990.

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