Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines.
BMC Res Notes. 2024 Jan 4;17(1):14. doi: 10.1186/s13104-023-06677-5.
Patients with coronavirus disease 2019 (COVID-19) and coronary artery disease (CAD) or heart failure (HF) are more likely to have poor outcomes. This study aimed to determine the characteristics and outcomes of COVID-19 patients with CAD/HF across various institutions in the Philippines.
We utilized the data from the Philippine CORONA Study and compared the outcomes of admitted COVID-19 patients with CAD/HF versus those without. The Student's t test, Mann-Whitney U test, binary logistic regression and multivariate regression analysis were utilized. Odds ratios (OR) and Kaplan-Meier curves were generated.
We included a total of 512 patients with COVID-19 had CAD/HF and 10,369 were without. CAD/HF was significantly associated with COVID severity, all-cause mortality, death from cardiac causes, respiratory failure, and prolonged hospitalization. After adjusting for confounders, the presence of CAD/HF was still associated with death from a cardiac cause (OR 2.22, 95% CI 1.49-3.3, p < 0.01).
The presence of CAD or HF was significantly associated with severity of COVID disease, all-cause mortality, death from cardiac causes, respiratory failure, and prolonged hospitalization.
患有 2019 年冠状病毒病（COVID-19）和冠心病（CAD）或心力衰竭（HF）的患者更有可能出现不良结局。本研究旨在确定菲律宾各医疗机构 COVID-19 合并 CAD/HF 患者的特征和结局。
我们利用菲律宾 CORONA 研究的数据，比较了住院 COVID-19 患者合并 CAD/HF 与不合并 CAD/HF 的结局。采用 Student's t 检验、Mann-Whitney U 检验、二项逻辑回归和多变量回归分析。生成比值比（OR）和 Kaplan-Meier 曲线。
我们共纳入 512 例 COVID-19 合并 CAD/HF 患者和 10369 例不合并 CAD/HF 患者。CAD/HF 与 COVID-19 严重程度、全因死亡率、心源性死亡、呼吸衰竭和住院时间延长显著相关。调整混杂因素后，CAD/HF 的存在仍与心源性死亡相关（OR 2.22，95%CI 1.49-3.3，p<0.01）。
CAD 或 HF 的存在与 COVID-19 疾病的严重程度、全因死亡率、心源性死亡、呼吸衰竭和住院时间延长显著相关。
