You Jee Young, Stoller James
Respiratory Institute, Division of Pulmonary and Critical Care Medicine Cleveland Clinic Cleveland Ohio USA.
Education and Respiratory Institute Cleveland Clinic Cleveland Ohio USA.
Respirol Case Rep. 2022 Apr 25;10(5):e0952. doi: 10.1002/rcr2.952. eCollection 2022 May.
Diffuse alveolar haemorrhage (DAH) after a generalized tonic-clonic seizure is a rarely described illness likely involving physical disruption of alveolar-capillary interface similar to the mechanism of neurogenic pulmonary oedema. Based on our review of the English literature, only 11 cases have been reported to date. Recognition of this sparsely reported entity is important for optimal management, including avoidance of medications that have been implicated in causing DAH. Current experience with two additional patients with post-ictal DAH extends the reported experience to 13 and summarizes what is, to our knowledge, the entire experience of such patients reported in the English literature. This case report highlights the key aspects of clinical presentation, radiological and pathological findings, clinical course and management implications with the goal of enhancing awareness of this condition by respiratory clinicians.
全身强直阵挛性发作后发生的弥漫性肺泡出血（DAH）是一种鲜有描述的疾病，其机制可能与神经源性肺水肿类似，涉及肺泡-毛细血管界面的物理性破坏。根据我们对英文文献的回顾，迄今为止仅报道了11例。认识这种报道较少的疾病实体对于优化管理很重要，包括避免使用与DAH发生有关的药物。目前另外两名发作后DAH患者的经验使报道的病例数增至13例，并总结了据我们所知英文文献中此类患者的全部经验。本病例报告突出了临床表现、放射学和病理学发现、临床病程及管理意义等关键方面，目的是提高呼吸科临床医生对该病的认识。
