Sun Xiaowei, Geng Yanling, Wang Xiao, Qin Dawei, Yu Jinqian
Qilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Shandong Key Laboratory of TCM Quality Control Technology Jinan 250014 P. R. China
School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of Sciences) Jinan 250353 Chin
RSC Adv. 2020 Jan 3;10(2):746-755. doi: 10.1039/c9ra09776g. eCollection 2020 Jan 2.
Eight new cembrane-type diterpenoids, boscartins AH-AK (1-8), along with two known ones (9-10), were isolated from the gum resin of . Compounds 1-3 were characteristic of high oxidation assignable to three epoxy groups, while compounds 4-8 were characteristic of two epoxy groups. Spectroscopic examination was used to elucidate their structures. All isolates were evaluated for antiproliferative activity against HCT-116 human colon cancer cells, anti-inflammatory activity against nitric oxide (NO) production, and hepatoprotective activity . All of them showed weak antiproliferative activity (IC > 100 μM), 8 exhibited potent inhibitory effects on NO production (IC of 14.8 μM), with the others showing weak anti-inflammatory activity (IC > 30 μM), and 1 exhibited more potent hepatoprotective activity than the positive control, bicyclol, at 10 μM against the damage induced by paracetamol in HepG2 cells.
从……的树胶脂中分离出8种新的cembrane型二萜类化合物，即波卡廷AH - AK（1 - 8），以及两种已知化合物（9 - 10）。化合物1 - 3具有三个环氧基导致的高氧化特征，而化合物4 - 8具有两个环氧基的特征。通过光谱分析来阐明它们的结构。对所有分离物进行了针对HCT - 116人结肠癌细胞的抗增殖活性、针对一氧化氮（NO）产生的抗炎活性以及肝脏保护活性评估。它们均表现出较弱的抗增殖活性（IC>100μM），8对NO产生具有强效抑制作用（IC为14.8μM），其他化合物表现出较弱的抗炎活性（IC>30μM），并且在10μM时，1对乙酰氨基酚诱导的HepG2细胞损伤表现出比阳性对照双环醇更强的肝脏保护活性。
