Hegazy Mohamed-Elamir F, Mohamed Tarik A, Elshamy Abdelsamed I, Hamed Ahmed R, Ibrahim Mahmoud A A, Ohta Shinji, Umeyama Akemi, Paré Paul W, Efferth Thomas
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Staudinger Weg 5 55128 Mainz Germany.
Chemistry of Medicinal Plants Department, National Research Centre El-Tahrir St., Dokki Giza 12622 Egypt
RSC Adv. 2019 Aug 29;9(47):27183-27189. doi: 10.1039/c9ra04158c.
A solvent extract of the soft coral afforded cembrene diterpenoids, sarcoehrenbergilid D-F (1-3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1-3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
一种软珊瑚的溶剂提取物得到了cembrene二萜类化合物，即sarcoehrenbergilid D - F（1 - 3）。通过现代光谱技术确定了化学结构，并通过圆二色性（CD）和含时密度泛函理论电子圆二色性计算（TDDFT - ECD）确定了绝对立体化学。针对三种人类癌细胞系：肺癌（A549）、结肠癌（Caco - 2）和肝癌（HepG2）评估了1 - 3的细胞毒性活性。
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