酿酒酵母的RAD24（= Rs1）基因产物参与两种不同的DNA修复途径。
The RAD24 (= Rs1) gene product of Saccharomyces cerevisiae participates in two different pathways of DNA repair.
作者信息
Eckardt-Schupp F, Siede W, Game J C
出版信息
Genetics. 1987 Jan;115(1):83-90. doi: 10.1093/genetics/115.1.83.
Abstract
The moderately UV- and X-ray-sensitive mutant of Saccharomyces cerevisiae originally designated rs1 complements all rad and mms mutants available. Therefore, the new nomination rad24-1 according to the RAD nomenclature is suggested. RAD24 maps on chromosome V, close to RAD3 (1.3 cM). In order to associate the RAD24 gene with one of the three repair pathways, double mutants of rad24 and various representative genes of each pathway were constructed. The UV and X-ray sensitivities of the double mutants compared to the single mutants indicate that RAD24 is involved in excision repair of UV damage (RAD3 epistasis group), as well as in recombination repair of UV and X-ray damage (RAD52 epistasis group). Properties of the mutant are discussed which hint at the control of late steps in the pathways.
摘要
酿酒酵母的中度紫外线和X射线敏感突变体最初命名为rs1，它能互补所有现有的rad和mms突变体。因此，建议根据RAD命名法将其重新命名为rad24-1。RAD24定位于第五条染色体上，靠近RAD3（1.3厘摩）。为了将RAD24基因与三种修复途径之一联系起来，构建了rad24与各途径中各种代表性基因的双突变体。与单突变体相比，双突变体对紫外线和X射线的敏感性表明，RAD24参与紫外线损伤的切除修复（RAD3上位组），以及紫外线和X射线损伤的重组修复（RAD52上位组）。文中讨论了该突变体的特性，这些特性暗示了对这些途径后期步骤的控制。
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