Ahmed Mohammed A M, Hussein Ahmed Mohamud, Abdullahi Aweis Ahmed Moalim, Ahmed Abdirizak Yusuf, Hussain Hamdi M A, Ali Abdiaziz Mohamed, Barre Abdulqadir Abdinur, Yusuf Farhia Mohamud, Olum Ronald, Sereke Senai Goitom, Elfadul Maisa Ahmed, Colebunders Robert, Bongomin Felix
Department of Paediatrics, Faculty of Medicine and Surgery, Mogadishu University, P.O. Box 004 KM4, Mogadishu, Somalia.
Faculty of Health Sciences, Mogadishu University, Mogadishu, Somalia.
Ther Adv Infect Dis. 2022 Apr 25;9:20499361221095731. doi: 10.1177/20499361221095731. eCollection 2022 Jan-Dec.
Coronavirus disease-2019 (COVID-19) is a potentially life-threatening illness with no established treatment. Cardiovascular risk factors (CRFs) exacerbate COVID-19 morbidity and mortality.
To determine the prevalence of CRF and clinical outcomes of patients hospitalized with COVID-19 in a tertiary hospital in Somalia.
We reviewed the medical records of patients aged 18 years or older with a real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 hospitalized at the De Martino Hospital in Mogadishu, Somalia, between March and July 2020.
We enrolled 230 participants; 159 (69.1%) males, median age was 56 (41-66) years. In-hospital mortality was 19.6% ( = 45); 77.8% in the intensive care unit (ICU) compared with 22.2%, in the general wards ( < 0.001). Age ⩾ 40 years [odds ratio (OR): 3.6, 95% confidence interval (CI): 1.2-10.6, = 0.020], chronic heart disease (OR: 9.3, 95% CI: 2.2-38.9, = 0.002), and diabetes mellitus (OR: 3.2, 95% CI: 1.6-6.2, < 0.001) were associated with increased odds of mortality. Forty-three (18.7%) participants required ICU admission. Age ⩾ 40 years (OR: 7.5, 95% CI: 1.7-32.1, = 0.007), diabetes mellitus (OR: 3.2, 95% CI: 1.6-6.3, < 0.001), and hypertension (OR: 2.5, 95% CI: 1.2-5.2, = 0.014) were associated with ICU admission. For every additional CRF, the odds of admission into the ICU increased threefold (OR: 2.7, 95% CI: 1.2-5.2, < 0.001), while the odds of dying increased twofold (OR: 2.1, 95% CI: 1.3-3.2, < 0.001).
We report a very high prevalence of CRF among patients hospitalized with COVID-19 in Somalia. Mortality rates were unacceptably high, particularly among those with advanced age, underlying chronic heart disease, and diabetes.
2019冠状病毒病（COVID-19）是一种可能危及生命的疾病，目前尚无既定的治疗方法。心血管危险因素（CRFs）会加剧COVID-19的发病率和死亡率。
确定索马里一家三级医院中因COVID-19住院患者的CRF患病率及临床结局。
我们回顾了2020年3月至7月在索马里摩加迪沙的德马蒂诺医院住院的18岁及以上经实时聚合酶链反应（RT-PCR）确诊为COVID-19患者的病历。
我们纳入了230名参与者；159名（69.1%）为男性，中位年龄为56岁（41 - 66岁）。住院死亡率为19.6%（n = 45）；重症监护病房（ICU）的死亡率为77.8%，而普通病房为22.2%（P < 0.001）。年龄≥40岁[比值比（OR）：3.6，95%置信区间（CI）：1.2 - 10.6，P = 0.020]、慢性心脏病（OR：9.3，95% CI：2.2 - 38.9，P = 0.002）和糖尿病（OR：3.2，95% CI：1.6 - 6.2，P < 0.001）与死亡几率增加相关。43名（18.7%）参与者需要入住ICU。年龄≥40岁（OR：7.5，95% CI：1.7 - 32.1，P = 0.007）、糖尿病（OR：3.2，95% CI：1.6 - 6.3，P < 0.001）和高血压（OR：2.5，95% CI：1.2 - 5.2，P = 0.014）与入住ICU相关。每增加一项CRF，入住ICU的几率增加两倍（OR：2.7，95% CI：1.2 - 5.2，P < 0.001），而死亡几率增加一倍（OR：2.1，95% CI：1.3 - 3.2，P < 0.001）。
我们报告了索马里因COVID-19住院患者中CRF的患病率非常高。死亡率高得令人无法接受，尤其是在老年、患有潜在慢性心脏病和糖尿病的患者中。
