Somal Navjot, Karan Ravi, Maharaj Aarti, Halperin Jeff, Boodhai Brent, Lipton Jeffrey, Masri Daniel J, Kumar Kamlesh
Maimonides Medical Center, USA.
Respir Med Case Rep. 2022 Apr 4;37:101647. doi: 10.1016/j.rmcr.2022.101647. eCollection 2022.
Sarcoidosis is a systemic inflammatory disease of unknown etiology with a myriad of clinical presentations depending on the organ systems involved. Neurosarcoidosis is an uncommon entity which is characterized by non-caseating granuloma infiltration of the central nervous system. Dysphagia in sarcoidosis is even more uncommon, and can involve one or more pathophysiological mechanisms: central nervous system involvement (cranial nerves associated with swallowing), lower motor neuron involvement (invasion of the enteric nervous plexus), direct muscle infiltration (invasion of the skeletal muscle portion of the esophagus and posterior pharynx), or mechanical obstruction (extrinsic compression by mediastinal lymph nodes). We report a case of a middle-aged woman presenting with severe dysphagia due to neurosarcoidosis which markedly improved after starting corticosteroids. The purpose of this case report is to highlight an atypical presentation of this disease.
结节病是一种病因不明的全身性炎症性疾病,根据受累的器官系统不同,有多种临床表现。神经结节病是一种罕见的疾病,其特征是中枢神经系统出现非干酪样肉芽肿浸润。结节病导致的吞咽困难更为罕见,可涉及一种或多种病理生理机制:中枢神经系统受累(与吞咽相关的颅神经)、下运动神经元受累(肠神经丛受侵犯)、直接肌肉浸润(食管和下咽的骨骼肌部分受侵犯)或机械性梗阻(纵隔淋巴结的外在压迫)。我们报告一例中年女性因神经结节病出现严重吞咽困难的病例,在开始使用皮质类固醇后症状明显改善。本病例报告的目的是突出这种疾病的非典型表现。