Sun Bingxia, Meng Yun, Song Tianlin, Shi Jieyun, He Xinhong, Zhao Peiran
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Front Chem. 2022 Apr 12;10:874641. doi: 10.3389/fchem.2022.874641. eCollection 2022.
Endogenic heat shock proteins and uneven local heat distribution are two main problems in traditional tumor hyperthermia therapy strategies. Aiming at solving these problems, we designed Au-SnSe-PVP nanomaterials (ASNPs) by modifying Au nanoparticles (Au-NPs) and biocompatible PVP on SnSe nanorods a new reactive oxygen species production strategy. The ASNPs with excellent photothermal conversion performance can produce thermoelectric effects in response to temperature differences during photothermal conversion. The modification of Au-NPs can attract free electron (e) to accumulate and promote the separation of e and holes (h) in the thermoelectric process, thereby further promoting e-rich Au-NPs-induced HO homolysis and h-HO half-reaction to generate hydroxyl radicals, realizing the synergistic application of photothermal therapy and pyroelectric dynamic therapy in tumor treatment.
内源性热休克蛋白和局部热分布不均是传统肿瘤热疗策略中的两个主要问题。为了解决这些问题，我们通过在硒化锡（SnSe）纳米棒上修饰金纳米颗粒（Au-NPs）和生物相容性聚乙烯吡咯烷酮（PVP）设计了金-硒化锡-聚乙烯吡咯烷酮纳米材料（ASNPs）——一种新的活性氧生成策略。具有优异光热转换性能的ASNPs在光热转换过程中可响应温度差产生热电效应。Au-NPs的修饰可吸引自由电子（e）积累并促进热电过程中e与空穴（h）的分离，从而进一步促进富含e的Au-NPs诱导的羟基自由基（HO）均裂和h-HO半反应以产生羟基自由基，实现光热疗法和热释电动力疗法在肿瘤治疗中的协同应用。
