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心脏病学中纳米技术的基本信息。

Essential information about nanotechnology in cardiology.

作者信息

Elendu Chukwuka, Amaechi Dependable C, Elendu Tochi C, Amaechi Emmanuel C, Elendu Ijeoma D, Omeludike Janet C, Omeludike Eunice K, Onubogu Nwamaka C, Ogelle Emmanuel C, Meduoye Oluwatobi O M, Oloyede Praise O, Ezeh Chiamaka P, Esangbedo Ikpembhosa J, Adigwe Augustina C, Akuma Nnachi M, Okafor Silas U

机构信息

Federal University Teaching Hospital, Owerri, Nigeria.

Igbinedion University, Okada, Nigeria.

出版信息

Ann Med Surg (Lond). 2025 Jan 31;87(2):748-779. doi: 10.1097/MS9.0000000000002867. eCollection 2025 Feb.

Abstract

Cardiology, as a medical specialty, addresses cardiovascular diseases (CVDs), a leading cause of global mortality. Nanomaterials offer transformative potential across key areas such as drug delivery, stem cell therapy, imaging, and gene delivery. Nanomaterials improve solubility, bioavailability, and targeted delivery in drug delivery, reducing systemic side effects. Examples include gas microbubbles, liposomal preparations, and paramagnetic nanoparticles, which show promise in treating atherosclerosis. Stem cell therapy benefits from nanotechnology through enhanced cell culture conditions and three-dimensional scaffolds that support cardiomyocyte growth and survival. Gold nanoparticles and poly(lactic-co-glycolic acid)-derived microparticles further improve stem cell viability. In imaging, nanomaterials enable advanced visualization techniques such as magnetic resonance imaging with direct labeling and optical tracking via dye-conjugated nanoparticles. In gene delivery, polymeric nanocarriers like polyethyleneimine, dendrimers, and graphene-based materials offer efficient, non-viral alternatives, with magnetic nanoparticles showing promise in targeted applications. Ongoing research highlights the potential of nanomaterials to revolutionize CVD management by improving therapeutic outcomes and enabling precision medicine. These advancements position nanotechnology as a cornerstone of modern cardiology.

摘要

心脏病学作为一门医学专业,主要研究心血管疾病(CVDs),这是全球死亡的主要原因。纳米材料在药物递送、干细胞治疗、成像和基因递送等关键领域具有变革潜力。在药物递送方面,纳米材料可提高药物的溶解度、生物利用度和靶向递送能力,减少全身副作用。例如,气体微泡、脂质体制剂和顺磁性纳米颗粒在治疗动脉粥样硬化方面显示出前景。干细胞治疗借助纳米技术,通过改善细胞培养条件和支持心肌细胞生长与存活的三维支架而受益。金纳米颗粒和聚乳酸 - 羟基乙酸共聚物衍生的微粒进一步提高了干细胞的活力。在成像领域,纳米材料使先进的可视化技术成为可能,如通过直接标记实现磁共振成像以及通过染料偶联纳米颗粒进行光学追踪。在基因递送方面,聚乙烯亚胺、树枝状大分子和基于石墨烯的材料等聚合物纳米载体提供了高效的非病毒替代方案,磁性纳米颗粒在靶向应用中显示出前景。正在进行的研究凸显了纳米材料通过改善治疗效果和实现精准医学来彻底改变心血管疾病管理的潜力。这些进展使纳米技术成为现代心脏病学的基石。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cd/11918598/0aef71f173ac/ms9-87-0748-g001.jpg

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