Hadzija M, Slijepcević M, Sverko V, Poljak-Blazi M
Horm Metab Res. 1987 Jan;19(1):6-10.
After immunization with SRBC, the number of plaque-forming cells (PFC) in the spleen of alloxan-diabetic mice, in nondiabetic TIR mice and in alloxan-diabetic TIR mice was significantly decreased as compared with control non-diabetic donors. The ability of lymphocytes from alloxan-diabetic mice to adoptively restore the suppressed immune response of TIR mice, was reduced in comparison with the effect of lymphocytes from normal, nondiabetic donors. Local GVH reaction in nondiabetic rat recipients provoked by lymphocytes from control healthy mice was 5.6 +/- 0.7 mm. Significantly lower rate of local GVH reaction after injection of lymphocytes from diabetic donors was found in diabetic as in nondiabetic recipients as well. Treatment of alloxan-diabetic mice with thymus extract or with insulin, partly restored depressed function of the humoral and cellular system. Treatment of diabetic mice with both thymus extract and insulin, was even more effective in restoring of their immune reactivity. Diabetic condition strongly influenced the function of the immune system. This could be attributed to depletion of T-lymphocytes, changed relations between the lymphocyte subpopulations in diabetic donors, and disturbance of lymphocyte metabolism.
用绵羊红细胞（SRBC）免疫后，与对照非糖尿病供体相比，四氧嘧啶糖尿病小鼠、非糖尿病TIR小鼠和四氧嘧啶糖尿病TIR小鼠脾脏中的空斑形成细胞（PFC）数量显著减少。与正常非糖尿病供体的淋巴细胞相比，四氧嘧啶糖尿病小鼠的淋巴细胞过继恢复TIR小鼠受抑制免疫反应的能力降低。对照健康小鼠的淋巴细胞在非糖尿病大鼠受体中引发的局部移植物抗宿主（GVH）反应为5.6±0.7毫米。在糖尿病受体和非糖尿病受体中，注射糖尿病供体的淋巴细胞后，局部GVH反应率均显著降低。用胸腺提取物或胰岛素治疗四氧嘧啶糖尿病小鼠，可部分恢复体液和细胞系统的功能抑制。用胸腺提取物和胰岛素同时治疗糖尿病小鼠，在恢复其免疫反应性方面更有效。糖尿病状态强烈影响免疫系统的功能。这可能归因于T淋巴细胞的耗竭、糖尿病供体中淋巴细胞亚群之间关系的改变以及淋巴细胞代谢的紊乱。
