Feng Huayang, Chu Dandan, Yang Fan, Li Zhanrong, Fan Bingbing, Jin Lin, Li Jingguo
Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, China.
Front Chem. 2020 Sep 4;8:742. doi: 10.3389/fchem.2020.00742. eCollection 2020.
Polymeric drug vectors have shown great potentials in cancer therapy. However, intelligent controlled release of drugs has become a major challenge in nanomedicine research. Hypoxia-responsive polymeric micelles have received widespread attention in recent years due to the inherent hypoxic state of tumor tissue. In this study, a novel diblock polymer consisting of polyethylene glycol and poly[glutamic acid (3-(2-nitro-imidazolyl)-propyl)] was synthesized and self-assembled into hypoxia-responsive polymeric micelles for the controlled release of doxorubicin (DOX). The cell experiments demonstrated that DOX-loaded micelles had a stronger killing capacity on tumor cells under hypoxic conditions, while the blank micelles had good biocompatibility. All the experiments indicate that our hypoxia-responsive polymeric micelles have a great potential for enhanced cancer treatment.
聚合物药物载体在癌症治疗中已显示出巨大潜力。然而，药物的智能控释已成为纳米医学研究中的一项重大挑战。由于肿瘤组织固有的缺氧状态，缺氧响应性聚合物胶束近年来受到了广泛关注。在本研究中，合成了一种由聚乙二醇和聚[谷氨酸(3-(2-硝基咪唑基)-丙基)]组成的新型二嵌段聚合物，并将其自组装成缺氧响应性聚合物胶束用于阿霉素(DOX)的控释。细胞实验表明，载有DOX的胶束在缺氧条件下对肿瘤细胞具有更强的杀伤能力，而空白胶束具有良好的生物相容性。所有实验表明，我们的缺氧响应性聚合物胶束在增强癌症治疗方面具有巨大潜力。
