聚偏氟乙烯膜长期生物过滤对酸碱平衡状态的影响：多中心研究

Effects of chronic biofiltration with PAN membranes on acid-base status: polycentric study.

作者信息

Tarchini R, Albertazzi A, Baroni C, Bordoni E, Buoncristiani U, Capponi E, Concetti M, Giombini L, Lombardo V, Ragaiolo M

出版信息

Int J Artif Organs. 1986 Dec;9 Suppl 3:17-20.

PMID:3549573

Abstract

Effects of chronic biofiltration (BF) with PAN membranes on acid-base status (ABS): polycentric study. From the 39 cases in a polycentric study we selected 13 patients with metabolic acidosis (pH 7.23 +/- 0.03), marked reduction of plasma bicarbonate (15.4 +/- 2.2 mEq/l) and hyperkalemia (6.2 +/- 0.6 mEq/l). BF was performed with a continuous post-dilutional supply of HCO3 (85 mmol/h), and attained rapid normalisation of blood bicarbonates and serum potassium during the treatment. After 6 months of BF treatment the pre-dialytic ABS showed remarkable improvement, and values were normal after one year. The remaining 26 patients in the polycentric study, treated by chronic BF without severe acidosis, showed good dialytic tolerance. In 15 of them the supply of bicarbonate was too high (because of moderate post-BF alkalosis) and we had to reduce the buffer inflow to about 50 mmol/h.

摘要

聚砜膜慢性生物滤过（BF）对酸碱状态（ABS）的影响：多中心研究。在一项多中心研究的39例患者中，我们选取了13例代谢性酸中毒患者（pH 7.23±0.03），其血浆碳酸氢盐显著降低（15.4±2.2 mEq/L）且伴有高钾血症（6.2±0.6 mEq/L）。采用持续后稀释法补充HCO₃（85 mmol/h）进行生物滤过，治疗期间血碳酸氢盐和血清钾迅速恢复正常。生物滤过治疗6个月后，透析前ABS显著改善，1年后各项指标恢复正常。多中心研究中其余26例接受慢性生物滤过但无严重酸中毒的患者，透析耐受性良好。其中15例患者碳酸氢盐补充量过高（因生物滤过后出现中度碱中毒），我们不得不将缓冲液输入量减少至约50 mmol/h。