Procaccini D A, Chiaravalle A, D'Altilia D, Delli Carri P, Di Gioia V, Muscio A, Salatino G, Tappi A, Passione A
Int J Artif Organs. 1986 Dec;9 Suppl 3:149-52.
The transmembrane transfer of calcium during hemodialysis is related to many factors (calcium gradient, plasma volume flow, plasma concentration of phosphate). During biofiltration the high ultrafiltration rate reduces the net transfer of calcium from dialysate to patient. Prolonged metabolic alkalosis occurs during biofiltration, lowering the ionized calcium/total calcium ratio. These two factors may stimulate PTH secretion, with negative long-term effects in dialysis bone disease.
血液透析过程中钙的跨膜转运与许多因素有关(钙梯度、血浆流量、血浆磷酸盐浓度)。在生物滤过过程中,高超滤率会降低钙从透析液向患者的净转运。生物滤过过程中会出现长时间的代谢性碱中毒,降低离子钙/总钙比值。这两个因素可能刺激甲状旁腺激素分泌,对透析骨病产生长期负面影响。