Liu Ya, Peng Bangzhu
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China.
Front Nutr. 2022 Apr 14;9:879354. doi: 10.3389/fnut.2022.879354. eCollection 2022.
To promote the normal metabolism of human uric acid, high-performance hyaluronic acid-black rice anthocyanins (HAA) nanocomposite particles were successfully prepared by a simple crosslinking method as a novel xanthine oxidase inhibitor. Its structure and properties were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectrometry (FT-IR), and X-ray diffraction (XRD). SEM and TEM electron microscopy showed an obvious double-layer spherical structure with a particle size of ~298 nm. FT-IR and XRD analysis confirmed that black rice anthocyanins (ATC) had been successfully loaded into the hyaluronic acid (HA) structure. Nanocomposite particles (embedded form) showed higher stability in different environments than free black rice ATC (unembedded form). In addition, the preliminary study showed that the inhibition rate of the nanocomposite particles on Xanthine oxidase (XO) was increased by 40.08%. These results indicate that HAA nanocomposite particles can effectively improve black rice ATC's stability and activity, creating an ideal new material for inhibiting XO activity that has a broad application prospect.
为促进人体尿酸的正常代谢，通过简单的交联方法成功制备了高性能透明质酸 - 黑米花青素（HAA）纳米复合颗粒，作为一种新型黄嘌呤氧化酶抑制剂。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、傅里叶变换红外光谱（FT - IR）和X射线衍射（XRD）对其结构和性能进行了表征。SEM和TEM电子显微镜显示出明显的双层球形结构，粒径约为298 nm。FT - IR和XRD分析证实黑米花青素（ATC）已成功负载到透明质酸（HA）结构中。纳米复合颗粒（包埋形式）在不同环境中比游离黑米ATC（未包埋形式）表现出更高的稳定性。此外，初步研究表明，纳米复合颗粒对黄嘌呤氧化酶（XO）的抑制率提高了40.08%。这些结果表明，HAA纳米复合颗粒可以有效提高黑米ATC的稳定性和活性，为抑制XO活性创造了一种具有广阔应用前景的理想新材料。
