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阿尔茨海默病连续体中多模态神经影像特征的全网络一致性。

Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.

作者信息

Stocks Jane, Popuri Karteek, Heywood Ashley, Tosun Duygu, Alpert Kate, Beg Mirza Faisal, Rosen Howard, Wang Lei

机构信息

Department of Psychiatry and Behavioral Sciences Feinberg School of Medicine Northwestern University Chicago Illinois USA.

School of Engineering Science Simon Fraser University Burnaby British Columbia Canada.

出版信息

Alzheimers Dement (Amst). 2022 Apr 26;14(1):e12304. doi: 10.1002/dad2.12304. eCollection 2022.

DOI:10.1002/dad2.12304
PMID:35496375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9043119/
Abstract

BACKGROUND

Concordance between cortical atrophy and cortical glucose hypometabolism within distributed brain networks was evaluated among cerebrospinal fluid (CSF) biomarker-defined amyloid/tau/neurodegeneration (A/T/N) groups.

METHOD

We computed correlations between cortical thickness and fluorodeoxyglucose metabolism within 12 functional brain networks. Differences among A/T/N groups (biomarker normal [BN], Alzheimer's disease [AD] continuum, suspected non-AD pathologic change [SNAP]) in network concordance and relationships to longitudinal change in cognition were assessed.

RESULTS

Network-wise markers of concordance distinguish SNAP subjects from BN subjects within the posterior multimodal and language networks. AD-continuum subjects showed increased concordance in 9/12 networks assessed compared to BN subjects, as well as widespread atrophy and hypometabolism. Baseline network concordance was associated with longitudinal change in a composite memory variable in both SNAP and AD-continuum subjects.

CONCLUSIONS

Our novel study investigates the interrelationships between atrophy and hypometabolism across brain networks in A/T/N groups, helping disentangle the structure-function relationships that contribute to both clinical outcomes and diagnostic uncertainty in AD.

摘要

背景

在脑脊液（CSF）生物标志物定义的淀粉样蛋白/ tau蛋白/神经退行性变（A/T/N）组中，评估了分布式脑网络内皮质萎缩与皮质葡萄糖低代谢之间的一致性。

方法

我们计算了12个功能性脑网络内皮质厚度与氟脱氧葡萄糖代谢之间的相关性。评估了A/T/N组（生物标志物正常[BN]、阿尔茨海默病[AD]连续体、疑似非AD病理变化[SNAP]）在网络一致性方面的差异以及与认知纵向变化的关系。

结果

在后部多模态和语言网络中，一致性的网络层面标志物可将SNAP受试者与BN受试者区分开来。与BN受试者相比，AD连续体受试者在评估的12个网络中有9个网络的一致性增加，同时存在广泛的萎缩和低代谢。基线网络一致性与SNAP和AD连续体受试者复合记忆变量的纵向变化相关。

结论

我们的新研究调查了A/T/N组中脑网络萎缩与低代谢之间的相互关系，有助于理清对AD临床结局和诊断不确定性都有影响的结构-功能关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/e7cd2768ca00/DAD2-14-e12304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/beacaa2211e8/DAD2-14-e12304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/e532d8e81d8f/DAD2-14-e12304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/1be629c578f3/DAD2-14-e12304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/cc84f0c8bb0d/DAD2-14-e12304-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/275805d74626/DAD2-14-e12304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/e7cd2768ca00/DAD2-14-e12304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/beacaa2211e8/DAD2-14-e12304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/e532d8e81d8f/DAD2-14-e12304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/1be629c578f3/DAD2-14-e12304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/cc84f0c8bb0d/DAD2-14-e12304-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/275805d74626/DAD2-14-e12304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/9043119/e7cd2768ca00/DAD2-14-e12304-g005.jpg

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1
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2
Reorganization of brain networks and its association with general cognitive performance over the adult lifespan.大脑网络的重组及其与成年后整体认知表现的关联。
Sci Rep. 2019 Aug 6;9(1):11352. doi: 10.1038/s41598-019-47922-x.
3
Brain metabolic patterns in patients with suspected non-Alzheimer's pathophysiology (SNAP) and Alzheimer's disease (AD): is [F] FDG a specific biomarker in these patients?
探究基于神经影像学的大脑年龄估计的时间模式作为阿尔茨海默病相关神经退行性变的生物标志物。
Neuroimage. 2022 Nov;263:119621. doi: 10.1016/j.neuroimage.2022.119621. Epub 2022 Sep 9.
疑似非阿尔茨海默病病理生理学 (SNAP) 和阿尔茨海默病 (AD) 患者的大脑代谢模式：[F] FDG 在这些患者中是否是一种特异性生物标志物？
Eur J Nucl Med Mol Imaging. 2019 Aug;46(9):1796-1805. doi: 10.1007/s00259-019-04379-4. Epub 2019 Jun 14.
4
Quantitative assessment of field strength, total intracranial volume, sex, and age effects on the goodness of harmonization for volumetric analysis on the ADNI database.基于 ADNI 数据库的体素分析，对场强、全脑容积、性别和年龄的调和优度进行定量评估。
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5
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Neuroimage. 2019 Jan 15;185:35-57. doi: 10.1016/j.neuroimage.2018.10.006. Epub 2018 Oct 3.
6
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