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一种用于合成()-1,2-二氢-2-亚氨基喹啉的简单高效的铜催化三组分反应。

A simple and efficient copper-catalyzed three-component reaction to synthesize ()-1,2-dihydro-2-iminoquinolines.

作者信息

Luo Xiai, Zhao Yu, Tao Susu, Yang Zhong-Tao, Luo Hui, Yang Weiguang

机构信息

Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University Zhanjiang 524023 China

The Marine Biomedical Research Institute of Guangdong Zhanjiang Zhanjiang Guangdong 524023 China.

出版信息

RSC Adv. 2021 Sep 29;11(50):31152-31158. doi: 10.1039/d1ra06330h. eCollection 2021 Sep 21.

DOI:10.1039/d1ra06330h
PMID:35496874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9041411/
Abstract

A operationally simple synthesis of ()-1,2-dihydro-2-iminoquinolines that proceeds under mild conditions is achieved by copper-catalyzed reaction of 1-(2-aminophenyl)ethan-1-ones, sulfonyl azides and terminal ynones. In particular, the reaction goes through a base-free CuAAC/ring-opening process to obtain the -configured products due to hydrogen bonding.

摘要

通过1-(2-氨基苯基)乙-1-酮、磺酰叠氮化物和末端炔酮的铜催化反应，实现了在温和条件下进行的() - 1,2 - 二氢 - 2 - 亚氨基喹啉的操作简单的合成。特别地，由于氢键作用，该反应通过无碱的铜催化的叠氮化物-炔环加成反应/开环过程来获得 - 构型产物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/37f94dfe7810/d1ra06330h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/a416a2ec2c3c/d1ra06330h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/d8a760a2d8ab/d1ra06330h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/2f8e22b000b7/d1ra06330h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/6fd211fdb793/d1ra06330h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/37f94dfe7810/d1ra06330h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/a416a2ec2c3c/d1ra06330h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/d8a760a2d8ab/d1ra06330h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/2f8e22b000b7/d1ra06330h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/6fd211fdb793/d1ra06330h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deaf/9041411/37f94dfe7810/d1ra06330h-s3.jpg

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