小檗碱治疗类风湿关节炎的疗效：从多靶点到治疗潜力。
Efficacy of berberine in treatment of rheumatoid arthritis: From multiple targets to therapeutic potential.
机构信息
National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, China; National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China.
National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China.
出版信息
Pharmacol Res. 2021 Jul;169:105667. doi: 10.1016/j.phrs.2021.105667. Epub 2021 May 11.
Rheumatoid arthritis is a systemic autoimmune disorder involved in persistent synovial inflammation. Berberine is a nature-derived alkaloid compound with multiple pharmacological activities in different pathologies, including RA. Recent experimental studies have clarified several determinant cellular and molecular targets of BBR in RA, and provided novel evidence supporting the promising therapeutic potential of BBR to combat RA. In this review, we recapitulate the therapeutic potential of BBR and its mechanism of action in ameliorating RA, and discuss the modulation of gut microbiota by BBR during RA. Collectively, BBR might be a promising lead drug with multi-functional activities for the therapeutic strategy of RA.
类风湿关节炎是一种全身性自身免疫性疾病，涉及持续的滑膜炎症。小檗碱是一种天然来源的生物碱化合物，具有多种药理学活性，涉及多种病理学，包括类风湿关节炎。最近的实验研究阐明了 BBR 在类风湿关节炎中的几个决定细胞和分子靶点，并提供了支持 BBR 对抗类风湿关节炎有潜在治疗作用的新证据。在这篇综述中，我们总结了 BBR 的治疗潜力及其在改善类风湿关节炎中的作用机制，并讨论了 BBR 在类风湿关节炎中对肠道微生物群的调节。总的来说，BBR 可能是一种有前途的多功能先导药物，可用于类风湿关节炎的治疗策略。
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