Frikha Rim
Department of Medical Genetics, Hedi Chaker University Hospital and Faculty of Medicine of Sfax, Sfax, Tunisia.
Indian J Hematol Blood Transfus. 2022 Apr;38(2):255-263. doi: 10.1007/s12288-021-01453-6. Epub 2021 May 26.
To clarify the effect of the A1298C variant of methylenetetrahydrofolate reductase () gene on the risk of acute lymphoblastic leukemia (ALL), an updated meta-analysis was performed. Electronic literature search was carried out in PubMed to collect relevant articles. Pooled odds ratios (OR) and stratification analysis were achieved under different genetic comparison models, age and ethnicity. A total of 46 articles including 7020 cases and 12,114 controls were enrolled. Overall, no significant association was observed for the A1298C variant on the risk of ALL in any genetic model test, when all the studies pooled together (OR ~ 1 0.91; > 0.05). In subgroup analyses stratified by age and ethnicity, the A1298C reduce the risk of ALL in adult under allele contrast (OR = 0.88; [0.72; 1.09], = 0.23) mainly in Caucasian populations. The present meta-analysis provides evidence that the A1298C variant of gene is unlikely to be a major risk gene for childhood ALL.
为阐明亚甲基四氢叶酸还原酶（MTHFR）基因的A1298C变异对急性淋巴细胞白血病（ALL）风险的影响，进行了一项更新的荟萃分析。在PubMed中进行电子文献检索以收集相关文章。在不同的基因比较模型、年龄和种族条件下实现了合并优势比（OR）和分层分析。共纳入46篇文章，包括7020例病例和12114例对照。总体而言，当所有研究合并在一起时，在任何基因模型测试中均未观察到A1298C变异与ALL风险之间存在显著关联（OR ~ 1.09；P > 0.05）。在按年龄和种族分层的亚组分析中，A1298C变异主要在白种人群体的等位基因对比中降低了成人ALL的风险（OR = 0.88；95%CI[0.72；1.09]，P = 0.23）。本荟萃分析提供的证据表明，MTHFR基因的A1298C变异不太可能是儿童ALL的主要风险基因。
