多取代吡唑的构建：碳酸钾介导生成的腈亚胺与肉桂醛的[3 + 2]环加成反应。

Construction of multi-substituted pyrazoles potassium carbonate-mediated [3 + 2] cycloaddition of generated nitrile imines with cinnamic aldehydes.

作者信息

Li Mei-Mei, Huang Hui, Tian Wanrong, Pu Yiru, Zhang Chaozheng, Yang Jirui, Ren Qing, Tao Feiyan, Deng Yun, Lu Jun

机构信息

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong Hong Kong SAR 999077 China.

出版信息

RSC Adv. 2022 Apr 29;12(21):13087-13092. doi: 10.1039/d2ra00331g. eCollection 2022 Apr 28.

A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction of hydrazonoyl chlorides with cinnamic aldehydes to furnish multi-substituted pyrazoles under nontoxic and mild conditions has been developed. A plausible stepwise cycloaddition reaction mechanism is proposed. This protocol featured broad substrate coverage, good functional group tolerance, wide scalability, and operational simplicity, as well as conveniently constructed pyrazole scaffolds.