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基于灰色关联分析策略的开喉剑喷雾剂抗炎质量标志物研究

Studies on Quality Markers of Kaihoujian Spray for Anti-Inflammation Based on Gray Correlation Analysis Strategy.

作者信息

Chen Jinpeng, Liu Yi, Gai Xiaohong, Ye Qing, Zhou Siyu, Tian Chengwang, Zhang Tiejun

机构信息

Tianjin Institute of Pharmaceutical Research, Tianjin, China.

Key Laboratory of TCM Quality Markers, Tianjin, China.

出版信息

Evid Based Complement Alternat Med. 2022 Apr 20;2022:1273066. doi: 10.1155/2022/1273066. eCollection 2022.

DOI:10.1155/2022/1273066
PMID:35497922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9045996/
Abstract

Kaihoujian spray (KHJ) was originated from the classical prescription of Miao medicine, which was commonly used for acute and chronic pharyngitis. The prescription was composed of Sophorae Tonkinensis Radix, Ardisiae Radix, Cicadae Periostracum, and menthol. However, in previous literature, only clinical studies have been reported. The Quality Marker (Q-Markers) of KHJ on anti-inflammation has not been clearly elucidated. In this study, a gray correlation analysis strategy combined with network pharmacology analysis was established for the investigation of Q-Markers in KHJ. A total of 52 components were identified or tentatively characterized in KHJ, including alkaloids, saponins, bergenin, flavonoids, amino acids, and their derivatives. Furthermore, regularity of recipe composition and gray correlation analysis revealed that the correlation degree of all peaks was greater than 0.5. The ranking of correlation degree was peak 1 > 6>9 > 8>7 > 10>4 > 5>11 > 3>2. Among them, peaks 2, 4, 5, 6, 8, 9, and 11 were identified as anagyrine, matrine, sophocarpine, norbergenin, bengenin, 11-O-galloylbergenin, and trifolirhizin. The network pharmacology analysis revealed that EGFR, MMP9, MMP3, MMP1, and PTGS2 were the main targets of KHJ. Bergenin, matrine, sophocarpine, calycosin, and trifolirhizin were the main anti-inflammatory active ingredient in KHJ. These results proposed that bergenin, sophocarpidine, sophocarpine, and trifolirhizin could be the Q-Markers of KHJ on anti-inflammation. The process of discovering the Q-Markers would provide a promising method of quality control on KHJ.

摘要

开喉剑喷雾剂（KHJ）源于苗族医学经典方剂，常用于急慢性咽炎。该方剂由山豆根、紫金牛、蝉蜕和薄荷脑组成。然而，以往文献中仅报道了临床研究。KHJ抗炎的质量标志物（Q-标志物）尚未明确阐明。本研究建立了灰色关联分析策略与网络药理学分析相结合的方法，以研究KHJ中的Q-标志物。KHJ中总共鉴定或初步表征了52种成分，包括生物碱、皂苷、岩白菜素、黄酮类、氨基酸及其衍生物。此外，方剂组成规律及灰色关联分析表明，所有峰的关联度均大于0.5。关联度排序为峰1＞6＞9＞8＞7＞10＞4＞5＞11＞3＞2。其中，峰2、4、5、6、8、9和11分别被鉴定为安那吉碱、苦参碱、槐果碱、去甲岩白菜素、岩白菜素、11-O-没食子酰岩白菜素和三叶豆紫檀苷。网络药理学分析表明，表皮生长因子受体（EGFR）、基质金属蛋白酶9（MMP9）,基质金属蛋白酶3（MMP3）、基质金属蛋白酶1（MMP1）和前列腺素内过氧化物合酶2（PTGS2）是KHJ发挥抗炎作用的主要靶点。岩白菜素 (bergenin)、苦参碱、槐果碱、毛蕊异黄酮和三叶豆紫檀苷是KHJ中主要的抗炎活性成分。这些结果表明，岩白菜素、槐果碱、苦参碱和三叶豆紫檀苷可能是KHJ抗炎的Q-标志物。Q-标志物的发现过程将为KHJ的质量控制提供一种有前景的方法。

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