Bajracharya Gan B
Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, Nepal.
Fitoterapia. 2015 Mar;101:133-52. doi: 10.1016/j.fitote.2015.01.001. Epub 2015 Jan 14.
Bergenin, a natural secondary metabolite, has been isolated from different parts of a number of plants. It is one of active ingredients in herbal and Ayurvedic formulations. It exhibits antiviral, antifungal, antitussive, antiplasmodial, antiinflammatory, antihepatotoxic, antiarrhythmic, antitumor, antiulcerogenic, antidiabetic and wound healing properties. It has been analyzed and estimated in different plant extracts, blood and drug samples using chromatographic techniques, and pharmacokinetic studies have been made. Several bergenin derivatives were isolated and/or synthesized and were found to possess pharmacological activities. Total synthesis of bergenin and its derivatives were reported. This review article covers literature on bergenin and its derivatives until 2013. Ethnomedicinal value of bergenin containing plant materials is also highlighted. This comprehensive review provides information on the potentiality of bergenin and its derivatives for therapeutic usages.
岩白菜素是一种天然次生代谢产物，已从多种植物的不同部位分离得到。它是草药配方和阿育吠陀配方中的活性成分之一。它具有抗病毒、抗真菌、止咳、抗疟原虫、抗炎、抗肝毒性、抗心律失常、抗肿瘤、抗溃疡、抗糖尿病和伤口愈合等特性。已使用色谱技术对不同植物提取物、血液和药物样品中的岩白菜素进行了分析和测定，并开展了药代动力学研究。分离和/或合成了几种岩白菜素衍生物，发现它们具有药理活性。报道了岩白菜素及其衍生物的全合成。这篇综述文章涵盖了截至2013年关于岩白菜素及其衍生物的文献。还强调了含岩白菜素植物材料的民族药用价值。这篇全面的综述提供了关于岩白菜素及其衍生物治疗用途潜力的信息。
