Dai Yu-Ting, Zhang Xue-Yan, Wang Yi-Xuan, Fan Yong-Sheng, Yang Dan, Liu Yong-Qi, Xiu Ming-Hui, He Jian-Zheng
School of Public Health, Gansu University of Chinese Medicine Lanzhou 730000, China.
Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China.
Zhongguo Zhong Yao Za Zhi. 2022 Apr;47(7):1754-1764. doi: 10.19540/j.cnki.cjcmm.20211213.201.
Astragali Radix, a medicinal herb for invigorating Qi, has anti-aging, anti-tumor, immunoregulatory, blood sugar-and lipid-lowering, anti-fibrosis, anti-radiation and other pharmacological effects. This article reviewed the studies about the chemical components and pharmacological effects of Astragali Radix. According to the theory of quality markers(Q-markers) of Chinese medicinal materials, we predicted the Q-markers of Astragali Radix from traditional efficacy, chemical component validity, measurability, plant phylogeny, and pharmacokinetis. The results showed that total polysaccharides, flavonoids(e.g., calycosin-7-O-β-D-glucoside, formononetin, calycosin, quercetin, and ononin), and saponins(e.g., astragalosides Ⅱ, Ⅲ, and Ⅳ) can be taken as the main Q-markers. This review lays a foundation for regulating the quality research and standard establishment of Astragali Radix, and benefits the control and quality supervision of the production process of Astragali Radix and its related products.
黄芪是一种补气的草药，具有抗衰老、抗肿瘤、免疫调节、降血糖和血脂、抗纤维化、抗辐射等药理作用。本文综述了黄芪化学成分和药理作用的研究。根据中药材质量标志物（Q-标志物）理论，从传统功效、化学成分有效性、可测性、植物系统发育和药代动力学等方面对黄芪的Q-标志物进行了预测。结果表明，总多糖、黄酮类化合物（如毛蕊异黄酮-7-O-β-D-葡萄糖苷、芒柄花素、毛蕊异黄酮、槲皮素和鹰嘴豆芽素）和皂苷类化合物（如黄芪甲苷Ⅱ、Ⅲ和Ⅳ）可作为主要的Q-标志物。本综述为规范黄芪质量研究和标准制定奠定了基础，有利于黄芪及其相关产品生产过程的控制和质量监督。
