Rodríguez-Romero José de Jesús, Durán-Castañeda Alba Cecilia, Cárdenas-Castro Alicia Paulina, Sánchez-Burgos Jorge Alberto, Zamora-Gasga Victor Manuel, Sáyago-Ayerdi Sonia Guadalupe
Tecnológico Nacional de México, Instituto Tecnológico de Tepic, Laboratorio Integral de Investigación en Alimentos, División de Estudios de Posgrado, Av. Tecnológico No 2595, Col. Lagos del Country CP 63175, Tepic, Nayarit, México.
Food Chem X. 2021 Dec 22;13:100195. doi: 10.1016/j.fochx.2021.100195. eCollection 2022 Mar 30.
Gut microbiota is a complex ecosystem of symbiotic bacteria that contribute to human metabolism and supply intestinal metabolites, whose production is mainly influenced by the diet. Dietary patterns characterized by a high intake of protein promotes the growth of proteolytic bacteria's, which produce metabolites from undigested protein fermentation. Microbioal protein metabolites can regulate immune, metabolic and neuronal responses in different target organs. Metabolic pathways of these compounds and their mechanisms of action on different pathologies can lead to the discovery of new diagnostic techniques, drugs and the potential use as functional ingredients in food. This review discusses the potential mechanisms by which amino acid catabolism is involved in microbial protein metabolites. In addition, results from several studies on the association of products from the intestinal metabolism of indigestible proteins and the state of health or disease of the host are revised.
肠道微生物群是一个由共生细菌组成的复杂生态系统，有助于人体新陈代谢并提供肠道代谢产物，其产生主要受饮食影响。以高蛋白质摄入为特征的饮食模式促进了蛋白水解细菌的生长，这些细菌通过未消化蛋白质发酵产生代谢产物。微生物蛋白质代谢产物可调节不同靶器官中的免疫、代谢和神经反应。这些化合物的代谢途径及其对不同病理状况的作用机制可能会带来新诊断技术、药物的发现以及作为食品功能成分的潜在用途。本综述讨论了氨基酸分解代谢参与微生物蛋白质代谢产物的潜在机制。此外，还对关于难消化蛋白质肠道代谢产物与宿主健康或疾病状态之间关联的多项研究结果进行了修订。
