单细胞RNA测序揭示了导致急性冠状动脉综合征的冠状动脉罪犯斑块中髓样细胞独特的免疫格局。 - Suppr

Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome.

作者信息

Emoto Takuo, Yamamoto Hiroyuki, Yamashita Tomoya, Takaya Tomofumi, Sawada Takahiro, Takeda Shintaro, Taniguchi Masayuki, Sasaki Naoto, Yoshida Naofumi, Saito Yoshihiro, Sivasubramaniyam Tharini, Otake Hiromasa, Furuyashiki Tomoyuki, Robbins Clinton S, Kawai Hiroya, Hirata Ken-Ichi

机构信息

Division of Cardiovascular Medicine, Department of Internal Medicine (T.E., T.Y., S.T., N.Y., Y.S., H.O., K.H.), Kobe University Graduate School of Medicine, Japan.

Division of Cardiovascular Medicine, Department of Internal Medicine, Hyogo Brain and Heart Center, Himeji, Japan (H.Y., T.T., T. Sawada, H.K.).

出版信息

Circulation. 2022 May 3;145(18):1434-1436. doi: 10.1161/CIRCULATIONAHA.121.058414. Epub 2022 May 2.

DOI:10.1161/CIRCULATIONAHA.121.058414

PMID:35500048

Abstract

摘要

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Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome.

作者信息

机构信息

Division of Cardiovascular Medicine, Department of Internal Medicine (T.E., T.Y., S.T., N.Y., Y.S., H.O., K.H.), Kobe University Graduate School of Medicine, Japan.

Division of Cardiovascular Medicine, Department of Internal Medicine, Hyogo Brain and Heart Center, Himeji, Japan (H.Y., T.T., T. Sawada, H.K.).

出版信息

Circulation. 2022 May 3;145(18):1434-1436. doi: 10.1161/CIRCULATIONAHA.121.058414. Epub 2022 May 2.

DOI:10.1161/CIRCULATIONAHA.121.058414

PMID:35500048

Abstract

摘要

相似文献

Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome.

Circulation. 2022 May 3;145(18):1434-1436. doi: 10.1161/CIRCULATIONAHA.121.058414. Epub 2022 May 2.

Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4 T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans-Brief Report.

Arterioscler Thromb Vasc Biol. 2024 May;44(5):1135-1143. doi: 10.1161/ATVBAHA.123.320409. Epub 2024 Apr 4.

[Assessment of Coronary Plaques in Patients With Acute Coronary Syndrome Without Persistent ST-Segment Elevation].

Kardiologiia. 2015;55(8):5-11. doi: 10.18565/cardio.2015.8.5-11.

Prognostic implications of non-culprit plaques in acute coronary syndrome: non-invasive assessment with coronary CT angiography.

Eur Heart J Cardiovasc Imaging. 2014 Nov;15(11):1231-7. doi: 10.1093/ehjci/jeu111. Epub 2014 Jun 17.

Predictors for layered coronary plaques: an optical coherence tomography study.

J Thromb Thrombolysis. 2020 Nov;50(4):886-894. doi: 10.1007/s11239-020-02116-5.

In vivo vulnerability grading system of plaques causing acute coronary syndromes: An intravascular imaging study.

Int J Cardiol. 2018 Oct 15;269:350-355. doi: 10.1016/j.ijcard.2018.06.115. Epub 2018 Jul 1.

Characteristics of non-culprit plaques in acute coronary syndrome patients with layered culprit plaque.

Eur Heart J Cardiovasc Imaging. 2020 Dec 1;21(12):1421-1430. doi: 10.1093/ehjci/jez308.

Pancoronary plaque vulnerability in patients with acute coronary syndrome and ruptured culprit plaque: a 3-vessel optical coherence tomography study.

Am Heart J. 2014 Jan;167(1):59-67. doi: 10.1016/j.ahj.2013.10.011. Epub 2013 Oct 19.

Gender and the extent of coronary atherosclerosis, plaque composition, and clinical outcomes in acute coronary syndromes.

JACC Cardiovasc Imaging. 2012 Mar;5(3 Suppl):S62-72. doi: 10.1016/j.jcmg.2012.02.003.

Characterization of culprit lesions in acute coronary syndromes using coronary dual-source CT angiography.

Atherosclerosis. 2010 Aug;211(2):437-44. doi: 10.1016/j.atherosclerosis.2010.02.001. Epub 2010 Feb 10.

引用本文的文献

Integrated single-cell atlas of human atherosclerotic plaques.

Nat Commun. 2025 Sep 10;16(1):8255. doi: 10.1038/s41467-025-63202-x.

FOS as a biomarker for myocardial infarction treatment with Deng's Yangxin Decoction: a systems biology-based analysis.

Front Cardiovasc Med. 2025 May 30;12:1488684. doi: 10.3389/fcvm.2025.1488684. eCollection 2025.

Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation.

Nat Immunol. 2025 May;26(5):706-721. doi: 10.1038/s41590-025-02132-8. Epub 2025 Apr 22.

Disturbed shear stress promotes atherosclerosis through TRIM21-regulated MAPK6 degradation and consequent endothelial inflammation.

Clin Transl Med. 2025 Jan;15(1):e70168. doi: 10.1002/ctm2.70168.

Integrated multi-omics profiling reveals neutrophil extracellular traps potentiate Aortic dissection progression.

Nat Commun. 2024 Dec 30;15(1):10736. doi: 10.1038/s41467-024-55038-8.

Disulfidptosis-related gene in acute myocardial infarction and immune microenvironment analysis: A bioinformatics analysis and validation.

PLoS One. 2024 Dec 12;19(12):e0314935. doi: 10.1371/journal.pone.0314935. eCollection 2024.

Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation.

Commun Biol. 2024 Dec 2;7(1):1601. doi: 10.1038/s42003-024-07308-w.

Dendritic cell-derived lncRNAs in patients with acute coronary syndrome.

J Cell Mol Med. 2024 Oct;28(20):e70057. doi: 10.1111/jcmm.70057.

Intense impact of IL-1β expressing inflammatory macrophages in acute aortic dissection.

Sci Rep. 2024 Jun 28;14(1):14893. doi: 10.1038/s41598-024-65931-3.

Molecular subtypes of ischemic heart disease based on circadian rhythm.

Sci Rep. 2024 Jun 19;14(1):14155. doi: 10.1038/s41598-024-65236-5.

Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome.

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Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome.

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