Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, Murcia, Spain.
Institute for Biomedical Research of Murcia (IMIB-Arrixaca), El Palmar, Murcia, Spain.
Reprod Domest Anim. 2022 Oct;57 Suppl 5(Suppl 5):4-13. doi: 10.1111/rda.14142. Epub 2022 May 15.
The establishment of a successful pregnancy can only occur through a concerted functioning of the entire female reproductive system, allowing for fertilization, subsequent embryo development and implantation of the conceptus. In this context, the uterine immunological responses responsible for rejection or tolerance of the conceptus are of critical importance. The aim of the present review is to summarize our current knowledge about those cellular and molecular immunological events occurring at the uterine level during pre-implantation and implantation stages of pregnancy in the pig. Advancing our understanding of the immune mechanisms involved in the success or failure of pregnancy will provide cues to develop novel strategies augmenting endometrial receptivity, finally increasing the efficiency of assisted reproductive technologies in pigs.
成功妊娠的建立只能通过整个女性生殖系统的协同作用来实现，允许受精、随后胚胎发育和胚胎着床。在这种情况下，子宫免疫反应对胚胎的排斥或耐受至关重要。本综述的目的是总结我们目前对猪在妊娠前植入和植入阶段子宫水平发生的细胞和分子免疫事件的认识。深入了解参与妊娠成功或失败的免疫机制将为开发新的策略提供线索，增强子宫内膜容受性，最终提高猪辅助生殖技术的效率。
