Meijers J H, Tibboel D, van der Kamp A W, Van Haperen-Heuts C C, Molenaar J C
J Pediatr Surg. 1987 Mar;22(3):243-5. doi: 10.1016/s0022-3468(87)80338-x.
Extensive studies in the chicken embryo have recently supplied more insights into the development of the enteric nervous system, which mainly derives from the vagal neural crest (i.e., the neural crest opposite somites 1 to 7). Crest cells migrate from this region to and via the developing gut. By means of a double labeling technique of both neural crest cells and cells in the S-phase of the cell cycle, we found that these migrating crest cells still proliferate in the gut. Some cells even go through cell division after the formation of a nerve plexus. Some implications for the pathogenesis of congenital innervation abnormalities such as hyperganglionosis and the aganglionosis of Hirschsprung's disease are discussed.
最近在鸡胚中进行的广泛研究为肠神经系统的发育提供了更多见解，肠神经系统主要起源于迷走神经嵴（即与第1至7体节相对的神经嵴）。嵴细胞从该区域迁移至发育中的肠道并途经肠道。通过对神经嵴细胞和细胞周期S期细胞进行双重标记技术，我们发现这些迁移的嵴细胞在肠道中仍会增殖。一些细胞甚至在神经丛形成后仍会进行细胞分裂。本文还讨论了这些发现对先天性神经支配异常（如神经节增生和先天性巨结肠症的无神经节症）发病机制的一些启示。
