Levine J D, Fye K, Heller P, Basbaum A I, Whiting-O'Keefe Q
J Rheumatol. 1986 Dec;13(6):1040-3.
A novel therapy for rheumatoid arthritis, regional sympathetic blockade using guanethidine, was investigated in 24 patients with active disease. In a randomized double blind short-term (14 days) study, we evaluated the effect of therapy on subjective responses, change in pain, stiffness, and morning stiffness and no objective responses, change in pinch strength, grip strength, and joint tenderness. Compared to placebo, guanethidine produced a decrease in pain (p less than 0.025) and an increase in pinch strength (less than 0.025) over the 2-week duration of the study. The therapeutic effect of guanethidine may be mediated by an interruption of the proinflammatory effects of the sympathetic nervous system.
对24例活动期类风湿关节炎患者研究了一种新型治疗方法，即使用胍乙啶进行区域交感神经阻滞。在一项随机双盲短期（14天）研究中，我们评估了该治疗对主观反应、疼痛变化、僵硬程度和晨僵的影响，以及对客观反应、捏力、握力和关节压痛变化的影响。与安慰剂相比，在为期2周的研究中，胍乙啶使疼痛减轻（p<0.025），捏力增加（p<0.025）。胍乙啶的治疗作用可能是通过中断交感神经系统的促炎作用来介导的。
