Yogya Yuri, Wanitphakdeedecha Rungsima, Wongdama Supisara, Nanchaipruek Yanisorn, Yan Chadakan, Rakchart Sarawalai
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Pran Nok Road, Bangkok, 10700, Thailand.
Innovative Skin and Laser Surgery (iSKY) Center, Bangkok, Thailand.
Dermatol Ther (Heidelb). 2022 May;12(5):1133-1145. doi: 10.1007/s13555-022-00729-7. Epub 2022 Apr 30.
A few studies have evaluated the efficacy and safety of noninsulated radiofrequency microneedling (RFMN) to treat periorbital wrinkles in Asian patients. Recently, wound healing accelerators, polynucleotides (PNs), have received attention in wound management. However, their efficacy and safety have not been fully elucidated following RFNM. This study aimed to evaluate the efficacy and safety of noninsulated RFMN for periorbital wrinkles and the synergistic effect of PNs after RFMN.
Thirty subjects with Fitzpatrick skin types III to V and facial wrinkles (Fitzpatrick grades I and II) were enrolled. All volunteers were treated over the entire face with noninsulated RFMN for three sessions at 2-week intervals. The left and right sides of each patient's face were randomly assigned to receive PNs (treatment group) or normal saline solution (control group). The indentation and maximum depth of wrinkles were objectively measured using Antera 3D. Subjective self-evaluations were obtained at baseline, 2 weeks after the third treatment, and at 1, 2, 3, and 6 months after the final treatment. In addition, pain scores, immediate reactions, and other adverse effects were evaluated.
Twenty-nine subjects completed the treatment protocol. Most presented with grade II wrinkling (69%). At 2-month follow-up, Antera 3D image analysis revealed faster improvement for the treatment group. At 6-month follow-up, the majority of subjects reported an improvement of 25-75% in their periorbital wrinkles. The average pain score was 2.2 out of 10. No serious adverse events (infection, pigmentary alteration, persistent erythema, or scarring) were observed.
Noninsulated RFMN is safe and effective for treating periorbital wrinkles and can be used as a modality for transdermal drug delivery. Topical polynucleotides as an adjunctive treatment provide additional benefits for periorbital wrinkle treatment.
TCTR20201105007.
一些研究评估了非绝缘射频微针（RFMN）治疗亚洲患者眶周皱纹的疗效和安全性。最近，伤口愈合促进剂多核苷酸（PNs）在伤口管理中受到关注。然而，在射频微针治疗后，其疗效和安全性尚未完全阐明。本研究旨在评估非绝缘RFMN治疗眶周皱纹的疗效和安全性以及射频微针治疗后多核苷酸的协同作用。
招募了30名皮肤菲茨帕特里克分型为III至V型且有面部皱纹（菲茨帕特里克分级为I和II级）的受试者。所有志愿者均接受非绝缘RFMN全脸治疗，共3次，间隔2周。每位患者面部的左右两侧随机分配接受多核苷酸（治疗组）或生理盐水溶液（对照组）。使用Antera 3D客观测量皱纹的凹陷程度和最大深度。在基线、第三次治疗后2周以及最后一次治疗后1、2、3和6个月进行主观自我评价。此外，评估疼痛评分、即时反应和其他不良反应。
29名受试者完成了治疗方案。大多数表现为II级皱纹（69%）。在2个月的随访中，Antera 3D图像分析显示治疗组改善更快。在6个月的随访中，大多数受试者报告眶周皱纹改善了25 - 75%。平均疼痛评分为10分制中的2.2分。未观察到严重不良事件（感染、色素改变、持续性红斑或瘢痕形成）。
非绝缘RFMN治疗眶周皱纹安全有效，可作为透皮给药的一种方式。局部使用多核苷酸作为辅助治疗可为眶周皱纹治疗带来额外益处。
TCTR20201105007。
