Li Ying, Zhao Wenjing, Wang Yanli, Wang Haiyan, Liu Shanglong
Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
Central Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
J Nanobiotechnology. 2022 May 2;20(1):208. doi: 10.1186/s12951-022-01382-0.
Pancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer progression. Extracellular vesicles (EVs), including exosomes and microvesicles, help facilitate an exchange of information both within the TME and to distant organs. EVs have also been identified as potential diagnostic biomarkers, therapeutic targets, and drug carriers for pancreatic cancer treatment. Thus, understanding the selective packaging of EVs cargo and its mechanistic impact will increase our understanding of cancer biology. In this review, we collect and analyze recent findings of the pancreatic cancer-stromal cell interactions mediated by EVs and the mechanisms involved in cancer-related immunity and chemoresistance. These studies demonstrate the vital role of EVs in pancreatic cancer reprogramming and TME remodeling. We also summarize the EVs identified as potential PDAC diagnostic biomarkers and possible therapeutic targets. This greater understanding is a promising avenue for transitioning EVs from bench to bedside.
胰腺导管腺癌（PDAC）与肿瘤微环境（TME）密切相互作用。TME通过胰腺癌细胞与基质细胞之间的串扰而重塑，并且对癌症进展至关重要。细胞外囊泡（EVs），包括外泌体和微囊泡，有助于促进TME内以及向远处器官的信息交换。EVs也已被确定为胰腺癌治疗的潜在诊断生物标志物、治疗靶点和药物载体。因此，了解EVs货物的选择性包装及其机制影响将增进我们对癌症生物学的理解。在本综述中，我们收集并分析了由EVs介导的胰腺癌-基质细胞相互作用以及癌症相关免疫和化疗耐药性所涉及机制的最新研究结果。这些研究证明了EVs在胰腺癌重编程和TME重塑中的重要作用。我们还总结了被确定为潜在PDAC诊断生物标志物的EVs以及可能的治疗靶点。这种更深入的理解是将EVs从实验室转化到临床应用的一条有前景的途径。
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